Serum IL-31 Linked to Itching in Hemodialysis Patients

MedicalResearch.com Interview wth:
Mei-Ju Ko, MD, PhD
Department of Dermatology, Taipei City Hospital
Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Medical Research: What are the main findings of the study?

Dr. Ko: In this study, not only did we find that serum levels of interleukin (IL)-31 were significantly higher in hemodialysis patients with pruritus symptoms, but we also demonstrated a positive exposure-response relationship between IL-31 levels and visual analog scale (VAS) scores of pruritus intensity. We also noted an inverse correlation between the severity of pruritus and the dialysis dose assessed by Kt/V.
Continue reading

Researchers Discuss Atrial Fibrillation and ZIO Service For Detection and Management

MedicalResearch.com Interview with:
Philip Gorelick, M.D., M.P.H, F.A.C.P. Medical Director of the Hauenstein Neuroscience Center Saint Mary’s Health Care, Grand Rapids, MI; Professor, Translational Science and Molecular Medicine Michigan State University College of Human Medicine; Board member of the National Stroke AssociationPhilip Gorelick, M.D., M.P.H, F.A.C.P.
Medical Director of the Hauenstein Neuroscience Center
Saint Mary’s Health Care, Grand Rapids, MI;
Professor, Translational Science and Molecular Medicine
Michigan State University College of Human Medicine;
Board member of the National Stroke Association
and
Judy Lenane, R.N., M.H.A. Chief Clinical Officer of iRhythm Technologies, Inc.

Judy Lenane, R.N., M.H.A.
Chief Clinical Officer of iRhythm Technologies, Inc.

 

Medical Research: What is atrial fibrillation and how common a problem is it among US adults?

Dr. Gorelick: Nearly 3 million people in the US suffer from Atrial Fibrillation or “Afib,” an abnormal heart rhythm that causes the heart to beat rapidly and irregularly. While Afib can occur at any age, the incidence increases with age and the number of cases is expected to increase significantly in the coming years as the population ages. Approximately 5 percent of people 65 years and older and one in every 10 people over 80 years of age have Afib. It is more common in those with high blood pressure, heart disease or lung disease. Continue reading

Diabetics with Acute Myocardial Infarction Have Higher Mortality

MedicalResearch.com Interview with:
Jorge F. Saucedo MD
Allstate Foundation, Judson B. Branch Chair of Cardiology
Head, Division of Cardiology
Co-Director Cardiovascular Institute
NorthShore University HealthSystem
Clinical Professor of Medicine
University of Chicago Pritzker School of Medicine

Talla A. Rousan, MD
Oklahoma City, OK.
First author of study.

Medical Research: What are the main findings of the study?

Answer: It was found that patients with diabetes mellitus (DM) presenting with acute myocardial infarction (AMI) have a higher in-hospital mortality rate compared to patients without DM. Patients with insulin-requiring diabetes mellitus presenting with non-ST-segment elevation myocardial infarction had higher in-hospital mortality rate than patients with non-insulin requiring diabetes mellitus.
Continue reading

Perjeta Extended Lives In Metastatic Breast Cancer

Giuseppe Curigliano M.D. Ph.D. Medico Direttore, Director Divisione Sviluppo Nuovi Farmaci per Terapie Innovative Early Drug Development for Innovative Therapies Division Via Ripamonti,  MilanoMedicalResearch.com Interview with:
Giuseppe Curigliano M.D. Ph.D.
Medico Direttore, Director
Divisione Sviluppo Nuovi Farmaci per Terapie Innovative
Early Drug Development for Innovative Therapies Division
Via Ripamonti,  Milano

Medical Research: What are the main findings of the study?

Dr. Curigliano: In the CLEOPATRA study, 808 patients from 25 countries with HER2-positive metastatic breast cancer were randomised to receive first-line placebo/trastuzumab/docetaxel or pertuzumab/trastuzumab/docetaxel. Randomisation was stratified by geographic region and neo/adjuvant chemotherapy.

At ESMO 2014 the CLEOPATRA researchers reported results of a final prespecified OS analysis (February 2014). This overall survival (OS) analysis was planned when ≥385 deaths were reported. The log-rank test, stratified by prior treatment status and geographic region, was used to compare OS between arms, applying the threshold of p ≤ 0.0456. Subgroup analyses of OS were performed for stratification factors and other key baseline characteristics.At median follow-up of 50 months (range 0 to 70 months), the statistically significant improvement in OS in favour of pertuzumab/trastuzumab/docetaxel arm was maintained (HR = 0.68, p = 0.0002). Median OS was 40.8 months in the placebo arm and 56.5 months in the pertuzumab arm, with difference of 15.7 months. The PFS in pertuzumab arm was 18.7 vs 12.4 months in placebo arm, HR 0.68 (p < 0.0001).
Continue reading

Adverse Reactions to Cephalosporin Antibiotics Reviewed

Eric Macy, MS, MS Allergy & Immunology Kaiser Permanente Medical Group-AllergyMedicalResearch.com Interview with:
Eric Macy, MS, MS
Allergy & Immunology
Kaiser Permanente Medical Group-Allergy

 

Medical Research: What are the main findings of the study?

Dr. Macy:

  • Cephalosporins are currently widely and relatively safely used in individuals with a history of a penicillin “allergy” in their medical record.
  • Cephalosporin associated anaphylaxis is very rare, even in individuals with a history of penicillin “allergy”.
  • Cephalosporin associated serious cutaneous adverse reactions are extremely rare.
  • Cephalosporin associated Clostridium difficile and serious nephropathy are relatively common.
    Continue reading

Moderate Physical Activity Could Protect Against Heart Failure in Women

dr_iffat_rahmanMedicalResearch.com Interview Invitation with:
Dr. Iffat Rahman Ph.D.
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden


Medical Research: What are the main findings of the study?

Dr. Rahman: Our study suggests that moderate to high level of physical activity could protect against heart failure in women.
Continue reading

Increasing Skirt Size Linked To Increased Breast Cancer Risk

MedicalResearch.com Interview with:
Professor Usha Menon,  Evangelia-Ourania Fourkala PhD
and Matthew Burrell PhD

Gynaecological Cancer Research Centre, Women’s Cancer, UCL EGA
Institute for Women’s Health, University College London, UK

Medical Research: What are the main findings of the study?

Response: Our study has shown that skirt size is a good proxy for central obesity. Each unit increase in UK skirt size every ten years between the age of 20 and 60 was associated with a 33% increase in postmenopausal breast cancer in our cohort.
Continue reading

Do Garlic Preparations Lower Blood Pressure?

MedicalResearch.com Interview with:
Prof. Dr. med. Alain Nordmann
Innere Medizin FMH
Basel, Switzerland

Medical Research: What are the main findings of the study?

Dr. Nordmann: Based on available randomised controlled trials, garlic preparations seem to lower blood pressure in individuals with hypertension in the short term. However, the quality of the studies and the lack of long-term data preclude the routine use of garlic preparations to lower blood pressure in individuals qualifying for antihypertensive drug therapy.
Continue reading

Aspirin Response Predicts Outcome After Stent Surgery

MedicalResearch.com Interview with:
Katharina Mayer MD
Deutsches Herzzentrum München,
Technische Universität München,
Munich, Germany

Medical Research: What are the main findings of the study?

Dr. Mayer: Patients whose platelets do not respond well to aspirin carry a higher risk of death or stent thrombosis. Platelet response to aspirin is an independent predictor of ischemic events in patients undergoing percutaneous coronary interventions (PCI).
Continue reading

Tallness May Be Protective Against Esophageal Cancer

Dr. Aaron P. Thrift PhD Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle, WA.MedicalResearch.com: Interview with:
Dr. Aaron P. Thrift PhD
Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Seattle, WA.


Medical Research: What are the main findings of the study?

Dr. Thrift: We conclude that height is inversely associated with risk of esophageal adenocarcinoma, both in men and women. The association is not due to confounding from known risk factors or bias.
Continue reading