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SUBLOCADE® (buprenorphine extended-release) in Patients Who Inject Opioids

MedicalResearch.com: What is the background for this study?

http://www.indivior.com/ Response: Adults with moderate or severe opioid use disorder (OUD) were randomized to SUBLOCADE monthly injections or placebo and studied for 24 weeks.

Participants receiving SUBLOCADE were given 2 monthly injections of 300 mg, followed by 4 monthly maintenance doses of 100 mg or 300 mg over the course of the study.

MedicalResearch.com: What are the main findings?

  • Opioid-injecting users experienced continued improvement in the proportion of participants achieving abstinence with the 300 mg maintenance dose; no significant improvement was noted with the 100 mg maintenance dose.
  • Safety profiles of 300 mg and 100 mg maintenance doses appeared comparable, including potential hepatic safety events.

Citation:

Weist et. Al. Examining the benefit of RBP-6000 300 mg versus 100 mg maintenance dose in opioid injectors. #W93. Presented at College on Problems of Drug Dependence (CPDD), June 23, 2021.

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Jun 24, 2021 @ 9:21 pm

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