Periodic Low Calorie Days Can Extend Lifespan (at least in mice)

MedicalResearch.com Interview with:

Valter Longo, PhD Edna M. Jones Professor of Gerontology  Professor of Biological Sciences Leonard Davis School of Gerontology Director of the USC Longevity Institute USC

Dr. Longo

Valter Longo, PhD
Edna M. Jones Professor of Gerontology
Professor of Biological Sciences
Leonard Davis School of Gerontology
Director of the USC Longevity Institute
USC

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The use of a low calorie diet that mimics fasting for 4 days twice a month starting at middle age can extend lifespan and rejuvenate mice.

In humans a similar diet once a month causes improvements in cholesterol, blood pressure , inflammation, fasting glucose etc consistent with rejuvenation

MedicalResearch.com: What should readers take away from your report?

Response: That the use of periodic fasting mimicking diets dine only 3-4 times per year can have major effects on aging and disease.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: The finding can be applied to many diseases so research can focus on many applications and the mechanisms responsible for its effects

Disclosures: I have equity interest in a company that makes medical food but I donate everything to charity.

Citation:

Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan , Navarrete G1, Dubeau L, Yap LP4, Park R4, Vinciguerra M5, Di Biase S1, Mir8zaei H1, Mirisola MG6, Childress P7Ji L8, Groshen S8, Penna F9, Odetti P10, Perin L2, Conti PS4, Ikeno Y11, Kennedy BK12, Cohen P1, Morgan TE1, Dorff TB13, Longo VD14.

Jan 15, 2019 @ 12:05 am 

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