20 Mar Atopic Dermatitis: Dupilumab Can Rapidly Improve Itch in Moderate to Severe Eczema
MedicalResearch.com Interview with:
Gil Yosipovitch, MD, Professor
Miami Itch Center
Lennar Medical Foundation
South Miami Clinic in Coral Gables
University of Miami Health System
MedicalResearch.com: What is the background for this study? How does Dupilumab (Dupixent) differ from other medications for atopic dermatitis/eczema?
Response: Atopic dermatitis (AD) is characterized by intense itch (pruritus) that is one of the most burdensome symptoms; therefore, rapid and sustained improvement in itch is an important marker of treatment benefit. Dupixent® (dupilumab) is approved in the U.S. for adults and adolescents with inadequately-controlled moderate-to-severe Atopic Dermatitis.
Dupilumab remains the first and only biologic medicine for uncontrolled moderate-to-severe atopic dermatitis. Dupilumab is the first and only fully human monoclonal antibody that inhibits the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) proteins. Data from dupilumab clinical trials have shown that IL-4 and IL-13 are key drivers of the type 2 inflammation that plays a major role in atopic dermatitis, asthma and chronic rhinosinusitis with nasal polyps.
MedicalResearch.com: What are the main findings?
Response: Dupilumab treatment demonstrated rapid improvement in itch in adult and adolescent patients with moderate-to-severe Atopic Dermatitis. Dupilumab was also generally well-tolerated with an acceptable safety profile.
Full results of rapid and sustained improvements in itch with dupilumab treatment from four Phase 3 trials with dupilumab in adults and adolescents with moderate-to-severe AD were recently published online in the Journal of the American Academy of Dermatology and available at: https://urldefense.proofpoint.com/v2/url?u=https-3A__www.jaad.org_article_S0190-2D9622-2820-2930305-2D4_fulltext&d=DwIGaQ&c=Dbf9zoswcQ-CRvvI7VX5j3HvibIuT3ZiarcKl5qtMPo&r=zx6i_bQM5Ja1G2nlZhcdgWskM3TYL9VgPbVi0-TRwDQ&m=MZWOSZLvqnINFnrl_YtEOFI2F4hlx2Jz-KkXrozslSo&s=FSccaqwy5V0qBUyuV2mZbjvDb7_W9FuYJOAe5mdxaO8&e=
MedicalResearch.com: What should readers take away from your report?
Response: Dupilumab treatment can improve symptoms after the first dose in some adult and adolescent patients with moderate-to-severe Atopic Dermatitis.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Future research assessing whether dupilumab could reduce itch associated with other skin conditions such as severe hand eczema, prurigo nodularis, and itch amongst elderly patients associated with immunosenescence.
MedicalResearch.com: Is there anything else you would like to add?
Response: The rapid response on itch precedes the effect on the atopic rash in both adults and adolescents, as itch is a key driver of the disease. It’s important to address this question and document it during an intake.
Disclosure: Yosipovitch G: Eli Lilly, Pfizer Galderma, Menlo Therapeutics, Novartis, Regeneron Pharmaceuticals, Inc., Sanofi, Trevi Therapeutics, Bellus, Kiniksa− advisory board member; Kiniksa, LEO Pharma, Pfizer, Sun − grants/research funding.
Dupilumab Treatment Results in Rapid Improvement in Itch in Adult and Adolescent Patients With Moderate-to-Severe Atopic Dermatitis (LIBERTY AD SOLO 1 & 2, and ADOL trials)
Yosipovitch, Gil et al.
Journal of Allergy and Clinical Immunology, Volume 145, Issue 2, AB190
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