After Outgrowing One Food Allergy, Some Patients Develop Second Allergic Reaction to Same Food

Jonathan M. Spergel, M.D., Ph.D. The Children's Hospital of Philadelphia Chief, Allergy Section Co-director, Center for Pediatric Eosinophilic Disorders Associate Professor of Pediatrics Perelman School of Medicine at the University of PennsylvaniaMedicalResearch.com Interview with:
Jonathan M. Spergel, M.D., Ph.D.
The Children’s Hospital of Philadelphia
Chief, Allergy Section
Associate Professor of Pediatrics
Perelman School of Medicine at the University of Pennsylvania

MedicalResearch.com: What are the main findings of the study?

Dr. Spergel: We were examining patients with Eosinophilic Esophagitis, an unique food allergy of the esophagus.   We found a subset of patients, who in the past had IgE mediated reaction to the food (hives, anaphylaxis) and had outgrown it.  Two-three years after outgrowing the food, then the patients developed Eosinophilic Esophagitis to the same food.
MedicalResearch.com: Were any of the findings unexpected?

Dr. Spergel: Yes, this finding indicated two important things:

  1. You can get two different reactions to the same food.
  2. The mechanism of the reactions for IgE-mediated reactions and Eosinophilic Esophagitis are different.

MedicalResearch.com:  What should clinicians and patients take away from your report?

Dr. Spergel: For patients and clinician, if someone has outgrown the food allergy.  But, then gets new symptoms, it could be the food that they had outgrown.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Dr. Spergel:  This research raises two important questions.

  1. How often does this happen?  How many patients that outgrown their food allergy will develop a different reaction to the same food?
  2. Is there a better to treat patients with Eosinophilc Esophagitis or food allergy due to this difference in mechanism?

Citation:

Maggadottir et al, “Development of Eosinophilic Esophagitis to Food after Development of IgE Tolerance to the Same Food, abstract 990, presented March 2, 2014 at the AAAAI Annual Meeting.

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