MedicalResearch.com Interview with:
Jonathan M. Spergel, M.D., Ph.D.
The Children’s Hospital of Philadelphia
Chief, Allergy Section
Associate Professor of Pediatrics
Perelman School of Medicine at the University of Pennsylvania
MedicalResearch.com: What are the main findings of the study?
Dr. Spergel: We were examining patients with Eosinophilic Esophagitis, an unique food allergy of the esophagus. We found a subset of patients, who in the past had IgE mediated reaction to the food (hives, anaphylaxis) and had outgrown it. Two-three years after outgrowing the food, then the patients developed Eosinophilic Esophagitis to the same food.
MedicalResearch.com: Were any of the findings unexpected?
Dr. Spergel: Yes, this finding indicated two important things:
- You can get two different reactions to the same food.
- The mechanism of the reactions for IgE-mediated reactions and Eosinophilic Esophagitis are different.
MedicalResearch.com: What should clinicians and patients take away from your report?
Dr. Spergel: For patients and clinician, if someone has outgrown the food allergy. But, then gets new symptoms, it could be the food that they had outgrown.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Dr. Spergel: This research raises two important questions.
- How often does this happen? How many patients that outgrown their food allergy will develop a different reaction to the same food?
- Is there a better to treat patients with Eosinophilc Esophagitis or food allergy due to this difference in mechanism?