Pre-Labor C-Section Affects Newborn’s Immune System

Professor of Pediatrics Hans Bisgaard, MD, DMSc Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital, University of Copenhagen, Denmark.

Prof. Bisgaard

MedicalResearch.com Interview with:
Professor of Pediatrics Hans Bisgaard, MD, DMSc
Copenhagen Prospective Studies on Asthma in Childhood
Herlev and Gentofte Hospital,
University of Copenhagen, Denmark

Medical Research: What is the background for this study?

Prof. Bisgaard: Programming of the immune response in perinatal life seems to contribute to the increased prevalence of immune-mediated diseases

We hypothesized that initiation of labor could affect the developing newborn immune system.

Medical Research: What are the main findings?

Prof. Bisgaard: Pre-labor cesarean section is associated with a distinct and gestational age-related distribution of circulating immune cells in newborns suggesting that changes in specific immune compartments occur during the approach of labor.

Medical Research: What should clinicians and patients take away from your report?

Prof. Bisgaard: This is research attempting to understand factors influencing early immune maturation.

Medical Research: What recommendations do you have for future research as a result of this study?

Prof. Bisgaar: Replication in a larger cohort.

Citation:

Prelabor cesarean section bypasses natural immune cell maturation

Thysen, Anna Hammerich et al.

Journal of Allergy and Clinical Immunology
Published Online: June 17, 2015
DOI: http://dx.doi.org/10.1016/j.jaci.2015.04.044

 

Pre-labor cesarean section is associated with a distinct and gestational age-related distribution of circulating immune cells in newborns (2015). Pre-Labor C-Section Affects Newborn’s Immune System MedicalResearch.com

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