MedicalResearch.com Interview with:
Terry Davies, MD, Professor
Medicine, Endocrinology, Diabetes and Bone Disease
Icahn School of Medicine at Mount Sinai
Co-Director, The Thyroid Center, Mount Sinai Union Square
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The receptor for thyroid stimulating hormone (TSH) is the major antigen for Graves’ disease and patients have unique antibodies to the TSHR which stimulate excessive thyroid hormone secretion.
We have characterized a variant TSHR called v1.3 which is a splicing variant which we find expressed in thyroid, bone marrow, thymus and adipose tissue and incorporates an intronic sequence which is fully translated.
MedicalResearch.com: What should readers take away from your report?
Response: This v1.3 binds TSH and TSHR antibodies and can act as a “pseudoreceptor” modulating their action. In addition, we describe new autoantibodies to the TSHR v1.3 which is, therefore, also a neoantigen.
We do not yet know if such antibodies have any clinical role in disease pathogenesis or natural history.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: We will be examining the role of these new antibodies in patients with autoimmune thyroid disease – both Graves’ patients and Hashimoto’s patients with a particular emphasis on patients with Graves’ ophthalmopathy who show very high levels of TSHR antibodies.
No relevant disclosures.
Endocrinology. 2019 Mar 1. pii: en.2018-01048. doi: 10.1210/en.2018-01048. [
Epub ahead of print]
A Modifying Autoantigen in Graves’ Disease.
Latif R1,2, Mezei M2, Morshed SA1,3, Ma R1,2, Ehrlich R1, Davies TF1,3.
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