05 Oct Acne Linked To Longer Telomeres and Better Aging
MedicalResearch.com Interview with:
Simone Ribero, M.D., Ph.D.
University of Turin
Department of Medical Sciences
Turin. Italy &
King’s College London
Department of Twin Research and Genetic Epidemiology
St Thomas’ campus
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: For many years dermatologists have identified that the skin of acne sufferers appears to age more slowly than in those who have not experienced any acne in their lifetime.
We have demonstrated in our paper that there is an association between acne and longer telomere length that means that acne patients , with the same anagraphic age , have a younger chronological age.
MedicalResearch.com: What should readers take away from your report?
Response: Acne is associated with longer telomere lengths and with better aging. We don’t know yet the practical implication of those results, but for sure there are some genetic background behind both the phenomenon. We are working on this finding in order to discover more about the genetic background of those two.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Of course knowing more in the field of acne would help in improving treatment in this very frequent disease, but at the same understanding the genetic profile of ageing is important in order to be able in future to fight against important age-related diseases
MedicalResearch.com: Is there anything else you would like to add?
Response: We also found out in the replication cohort that acne patients showed a differential expression of a gene involved in the apoptosis pathway.
This is a confirmation that ageing, senescence and programmed cells death are associated with acne .
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
S. Ribero, M. Sanna, A. Visconti, A. Navarini, A. Aviv, D. Glass, T.D. Spector, C. Smith, M. Simpson, J. Barker, M. Mangino, M. Falchi, V. Bataille. Acne and telomere length. A new spectrum between senescence and apoptosis pathways.
Journal of Investigative Dermatology, 2016; DOI:10.1016/j.jid.2016.09.014
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