MedicalResearch.com: What is the background for this study?
Response: Acidosis is usually noted in advanced chronic kidney disease (CKD) while it is relatively unexplored whether changes in the undetermined anions, as measured by anion gap occur earlier in the course of CKD.
Consumption of animal-sourced protein is acid-inducing and therefore such diet presumably increases undetermined anions. Since higher dietary acid load is associated with progression of CKD, we wanted to explore whether the increase in undetermined anions in moderate CKD is associated with CKD progression.
MedicalResearch.com: What are the main findings?
Response: In our study, we found that anion gap was independently associated with risk of ESRD in adults with moderate CKD.
MedicalResearch.com: What should readers take away from your report?
Response: We identified anion gap as a novel risk factor for CKD progression. It is a potential therapeutic target for slowing CKD progression.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Anion gap may have a mechanistic role in acid-induced kidney progression and identifying risk profiles for anion gap at an early stage will help elucidate pathways in CKD progression.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Citation: ASN 2016 Abstract
Anion Gap Associated with Risk of Progression to ESRD in Adults with Moderate CKD
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