18 Feb Avocado Substituted Diets Improve Lipid Profile
MedicalResearch.com Interview with:
Sachin A. Shah, Pharm.D.
Residency Director & Regional Coordinator –
Associate Professor of Pharmacy Practice
TJ Long School of Pharmacy and Health Sciences
University of the Pacific
Medical Research: What is the background for this study? What are the main findings?
Dr. Shah: The link between serum cholesterol and cardiovascular mortality has been well established. Dietary sources of cholesterol can play a major role toward a beneficiary or unfavorable lipid profile. Fatty acids in foods typically fall within one of the four categories: saturated fats (SFAs), common in animal sources, trans fats (TFAs), common in processed foods, polyunsaturated fats (PUFAs), and monounsaturated fats (MUFAs), both common in plant-derived sources. Although low-fat diets are generally recommended, studies have indicated that altering the types of fats you consume may further modify the risk of dyslipidemia. We performed a meta-analysis of existing studies to determine the impact of avocados on the lipid profile.
Ten unique studies incorporating 229 subjects were included. Avocado consumption significantly reduced TC, LDL-C, and TG by 18.80 mg/dL, 16.50 mg/dL, 27.20 mg/dL respectively. HDL-C decreased non-significantly.
Medical Research: What should clinicians and patients take away from your report?
Dr. Shah: Avocado-substituted diets significantly benefit the lipid profile. Substituting dietary fats with avocados versus adding to the free diet should be the primary recommendation strategy.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Shah: Larger feeding studies assessing novel markers such as
LDL-C particle size, or LDL-C subclass, are warranted.
Differences in the types of avocado, and the ideal amount of avocado to be consumed needs further investigation.
Medical Research: Is there anything else you would like to add?
Dr. Shah: Diet based interventions can have a great degree of lipid profile benefits and their use should be further employed.
Peou, Sokunthea et al. Journal of Clinical Lipidology , Volume 10 , Issue 1 , 161 – 171
Sokunthea Peou, PharmD ,Brittany Milliard-Hasting, MD ,Sachin A. Shah, PharmD
Dr. Sachin Shah (2016). Avocado Substituted Diets Improve Lipid Profile MedicalResearch.com