Blood Test May Distinguish Osteoarthritis From Rheumatoid Arthritis

Dr Naila Rabbani Reader of Experimental Systems Biology Protein Damage and Systems Biology Research Group, Division of Metabolic & Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, University Hospital U.K. MedicalResearch.com Interview with:
Dr Naila Rabbani
Reader of Experimental Systems Biology
Protein Damage and Systems Biology Research Group, Division of Metabolic & Vascular Health, Warwick Medical School, University of Warwick,
Clinical Sciences Research Laboratories, University Hospital U.K.

Medical Research: What is the background for this study? What are the main findings?

Dr Rabbani: We performed a study to investigate biochemical markers indicative of early-stage decline in joint health and development of early-stage osteoarthritis OA), rheumatoid arthritis (RA) and other inflammatory joint disease. The main finding was that by combining measures of three substances in blood – citrullinated protein (CPs), antibodies to CPs and hydroxyproline we could detect and discriminate between early-stage osteoarthritis and rheumatoid arthritis.

Medical Research: What should clinicians and patients take away from your report?

Dr Rabbani: With a simple blood-based assay it is possible to detect and discriminate between early-stage osteoarthritis and rheumatoid arthritis.

Medical Research: What recommendations do you have for future research as a result of this study?

Dr Rabbani: Further studies will preferably work towards making the test readily available to doctors, investigate the link between these markers and how rapidly early-stage OA and RA develop to more advanced disease, and assess the use of this test in evaluation of treatments for early-stage osteoarthritis and RA.

Citation:

Usman Ahmed, Attia Anwar, Richard S. Savage, Matthew L. Costa, Nicola Mackay, Andrew Filer, Karim Raza, Richard A. Watts, Paul G. Winyard, Joanna Tarr, Richard C. Haigh, Paul J. Thornalley, Naila Rabbani. Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health. Scientific Reports, 2015; 5: 9259 DOI: 10.1038/srep09259

MedicalResearch.com Interview with: Dr Naila Rabbani (2015). Blood Test May Distinguish Osteoarthritis From Rheumatoid Arthritis