Response: An inverse relationship between coffee consumption and mortality has been reported in the general population. However, the association between caffeine consumption and mortality in patients with chronic kidney disease (CKD) remains unclear. We examined the association between varying levels of caffeine consumption and mortality among 2328 patients with CKD in a prospective nationwide cohort, using the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2010.
A dose-dependent inverse association between caffeine and all-cause mortality was observed in patients with CKD. This association was independent of influential factors including age, gender, race, annual family income, education level, estimated GFR, albumin/creatinine ratio, hypertension, smoking status, dyslipidemia, body mass index, previous cardiovascular events and diet: consumption of alcohol, carbohydrates, polyunsaturated fatty acids and fibers.
Comparing with 1st quartile of caffeine consumption, adjusted HR for death was 0.88 (95% CI, 0.68-1.44) for 2nd quartile, 0.78 (95% CI, 0.60-1.01) for 3rd quartile and 0.76 (95% CI, 0.59-0.97) for 4th quartile (p=0.027 for trend across quartiles)
MedicalResearch.com: What should clinicians and patients take away from your report?
Response: Our study showed a dose-dependent protective effect of caffeine consumption on all-cause mortality among patients with CKD.
However, our observational study cannot prove that caffeine reduces the risk of death but only suggests the possibility of such a protective effect.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Future research should focus on the benefits and harms of other compounds present in caffeine-containing beverages, and on the study of the association between caffeine consumption and mortality in other world regions.
This investigation resulted from teamwork of five investigators: Miguel Bigotte Vieira, Rita Magriço, Catarina Viegas Dias, Lia Leitão, João Sérgio Neves. No funding was received for the completion of this study.
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Citation: ASN week 2017 abstract November 3 2017
Caffeine Consumption and Mortality in CKD
Bigotte Vieira, Miguel, et al
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