23 Nov Concussion: Gray Matter Abnormalities vs Self-Reported Symptoms
MedicalResearch.com: What are the main findings of the study?
a) Just because mTBI patients self-report reduced and/or no post-concussive symptoms does not mean that they have completed the healing process.
b) Current gold-standards in the clinical world (CT scans and self-report) may not be accurately capturing brain health after injury.
c) Diffusion imaging shows promise for being a more sensitive biomarker for measuring recovery than currently used techniques.
MedicalResearch.com Were any of the findings unexpected?
Dr. Mayer: No. We have observed similar findings previously in both adult and pediatric patients.
MedicalResearch.com What should clinicians and patients take away from your report?
Dr. Mayer: The field only has a preliminary understanding of the pathophysiological effects of mTBI/concussion and the subsequent recovery from these injuries. More work is needed to develop objective bio-markers about when it is truly safe to return to physical activities.
MedicalResearch.com What recommendations do you have for future research as a result of this study?
Dr. Mayer: The current results are based on small sample (50 mTBI patients) and need to be replicated in an independent study. Objective characterization of concussion is a must for the field to move forward.