MedicalResearch.com Interview with:
Wisit Cheungpasitporn, MD, Nephrology Fellow
Program director: Suzanne Norby, MD
Project mentors: Stephen B. Erickson, MD
and John C. Lieske, MD
Departments of Nephrology and Hypertension
Mayo Clinic, Rochester, MN
MedicalResearch: What is the background for this study?
Dr.Cheungpasitporn: Kidney stones are very common urologic problems. In addition, once someone has a kidney stone, the likelihood of having another episode increases to 50% within 5 years. Increased fluid intake has been suggested as a simple strategy for kidney stone prevention. However the data on conclusions regarding the benefit, adherence and safety of high fluid intake for the primary or secondary prevention of stones were limited. Thus, we conducted this meta-analysis to evaluate the treatment effect of high fluid intake on the incidence of kidney stones, and to assess the compliance and safety of high fluid intake to prevent kidney stones. Our data presented at the National Kidney Foundation’s 2015 Spring Clinical Meetings may help improve clinicians’ ability to manage kidney stones.
MedicalResearch: What are the main findings?
Dr.Cheungpasitporn: Our meta-analysis included 9 studies with 273,954 patients. According to the findings of our study, individuals with daily high fluid intake (to achieve a urine volume of at least 2.0‒2.5 L per day) had lower risk of new kidney stones by approximately 50%. High fluid intake provided the same benefit in men and women. In addition, high fluid intake reduced the risk of recurrent kidney stones by 40%. Overall, high fluid intake is safe with low adverse events.
MedicalResearch: What should clinicians and patients take away from your report?
Dr.Cheungpasitporn: Our study confirmed the effectiveness of water therapy. Protective effect of high fluid intake against stone formation by increasing the urine flow rate and urine volume is likely the key. Our study clearly demonstrates a reduction in the risk of new and recurrent kidney stones among individuals with high fluid intake. The magnitude of risk reduction is high.
MedicalResearch: What recommendations do you have for future research as a result of this study?
Dr.Cheungpasitporn: Kidney stones have recently been linked to many comorbid conditions including hypertension, diabetes, kidney disease and heart diseases. It would be nice if we can further identify the effects of high fluid intake on the reduction of those kidney stone related comorbidities.
MedicalResearch.com Interview with:, & Wisit Cheungpasitporn, MD, Nephrology Fellow (2015). High Fluid Intake Reduces Risk Of New Kidney Stones MedicalResearch.com