Medical Research: What is the background for this study?
Dr. Gewirtz: 2010 science paper that discovered that loss of toll-like receptor 5 altered gut microbiota to drive metabolic syndrome
Medical Research: What are the main findings?
Dr. Gewirtz: It is loss of tlr5 on epithelial cells that alters the microbiota to make it more pro-inflammatory that drives metabolic syndrome.
Medical Research: What should clinicians and patients take away from your report?
Dr. Gewirtz: Failure to manage the gut microbiota can result in a an inflammatory microbiota that drives metabolic syndrome.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Gewirtz: Will be importanat to develop ways to control an aberrant microbiota to make it less pro-inflammatory.
Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in MiceBy: Marie Benz MD FAAD
Chassaing B, Ley RE, Gewirtz AT
Gastroenterology. 2014 Aug 27. pii: S0016-5085(14)01072-5. doi: 10.1053/j.gastro.2014.08.033. [Epub ahead of print]