15 Apr Intestinal Bacteria May Decrease Cancer Risk By Reducing Inflammation
MedicalResearch.com Interview with:
Robert H. Schiestl PhD
Department of Environmental Health Sciences, Fielding School of Public Health,
Department of Pathology
Department of Radiation Oncology
Geffen School of Medicine
University of California Los Angeles,
Los Angeles, California
Medical Research: What is the background for this study? What are the main findings?
Dr. Schiestl: When we moved from Harvard to UCLA 13 years ago, after 6 years at UCLA our Atm mouse colony lived significantly 4 fold longer and the frequency of DNA deletions was 4.5 fold reduced and the latency of lymphoma 2.5 fold different. Ultimately we identified the reason behind this as a difference in the intestinal bacteria. The Atm deficient mice are hypersensitive to inflammation and the bacteria reduced inflammation. Then I isolated the most prevalent bacterium among the health beneficial bacteria and this bacterium by itself called Lactobacillus johnsonii 456 reduced genotoxicity and all markers of inflammation.
Medical Research: What should clinicians and patients take away from your report?
Dr. Schiestl: Inflammation causes all cancers, neurodegenerative disease, heart disease, inflammable bowel disease, ulcerative colitis, Lupus, celiac disease, arthritis, asthma and ageing. So a reduction of inflammation should reduce the risk of all those diseases. We have a company, Microbio Pharma, Holding Inc www.microbiopharma.com which produces the bacteria and currently sells Kombucha but will sell also Yogurt, Kefir and capsules with the bacteria.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Schiestl: Identifying further health beneficial bacteria to put into the health beneficial capsules and health detrimental bacteria to design baceriophages to kill them.
Medical Research: Is there anything else you would like to add?
Dr. Schiestl: We are very excited to improve the health of everyone.
Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis
Amrita K. Cheema , Irene Maier , Tyrone Dowdy, Yiwen Wang, Rajbir Singh,
Paul M. Ruegger, James Borneman, Albert J. Fornace Jr, Robert H. Schiestl
Published: April 13, 2016 http://dx.doi.org/10.1371/journal.pone.0151190