06 Oct Intestinal Bacteria May Play A Role in Anorexia Nervosa
Medical Research: What is the background for this study? What are the main findings?
Dr. Carroll: Anorexia nervosa (AN) is a severe psychiatric disorder characterized by extreme weight dysregulation and presents with high rates of comorbid anxiety.Anorexia nervosa carries the highest mortality rate of all psychiatric illnesses and relapse is frequent. Although a prime contributor, genetic factors do not fully account for the etiology ofAnorexia nervosa, and non-genetic factors that contribute to the onset and persistence of this disease warrant investigation. Compelling evidence that the intestinal microbiota regulates adiposity and metabolism, and more recently, anxiety behavior, provides a strong rationale for exploring the role of this complex microbial community in the onset, maintenance of, and recovery from Anorexia nervosa. Our study provides evidence of an intestinal dysbiosis in AN and an association between mood and the enteric microbiota in this patient population.
Medical Research: What should clinicians and patients take away from your report?
Dr. Carroll: Currently available treatments for Anorexia nervosa are suboptimal. In addition, the process of weight gain and renourishment can be extremely uncomfortable for patients. Often, patients are discharged from the hospital and within months and sometimes weeks, find themselves losing weight again and facing readmission. If targeting the intestinal microbiota in patients with Anorexia nervosa could make renourishment less uncomfortable, help patients regulate their weight, and positively affect behavior, then there is the potential for fewer readmissions and more cures.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Carroll: Although genetic and neurobiological research underscores that Anorexia nervosa is most accurately considered a biologically based mental illness, the neurobiology of Anorexia nervosa remains an enigma, which has hindered the development of novel, safe, and effective treatments. Our findings are an important first step in uncovering the role of the intestinal microbiota in AN. Future mechanistic studies examining the impact of specific taxa on behavior and adiposity, including transplantation of the intestinal microbiota of patients with AN into gnotobiotic mice, will allow us to distinguish between microbial markers of renourishment and recovery from psychopathology and move us even closer to designing innovative therapies for AN targeting enteric microorganisms.
Susan C. Kleiman, Hunna J. Watson, Emily C. Bulik-Sullivan, Eun Young Huh, Lisa M. Tarantino, Cynthia M. Bulik, Ian M. Carroll. The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment.Psychosomatic Medicine, 2015; 1 DOI: 1097/PSY.0000000000000247
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Dr. Ian Carroll, PhD (2015). Intestinal Bacteria May Play A Role in Anorexia Nervosa