Low Sugar Diet Reduced Liver Fat and Inflammation

MedicalResearch.com Interview with:

Miriam Vos, MD, MSPH Assistant professor of Pediatrics Emory University School of Medicine Physician on staff, Children’s Healthcare of Atlanta

Dr. Vos

Miriam Vos, MD, MSPH
Associate Professor of Pediatrics and Director
Pediatric Fatty Liver Program
Emory and Children’s Healthcare of Atlanta

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Fatty liver disease has quickly become a common problem in children and adolescents, affecting an estimated 7 million children in the U.S.  This study resulted from our previous research demonstrating that fructose increases cardiometabolic risk factors in children with NAFLD in addition to other research that had demonstrated associations between NAFLD and sugar.   

MedicalResearch.com: What should readers take away from your report?

Response: In this study, we proved that an 8 week reduction of dietary sugar to very low levels, reduces the fat in the liver and the inflammation.  This is a remarkable improvement for the short amount of time, however this study did not test if the effect lasts longer than 8 weeks.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: This was a very intensive study in which we gave families all of their food.  The next step will be to conduct a longer study, testing if the diet can be managed by families and if the effect continues to improve and hopefully normalize the liver over 1-2 years.

The disclosures are all listed in the article.  


Schwimmer JB, Ugalde-Nicalo P, Welsh JA, et al. Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial. JAMA. 2019;321(3):256–265. doi:10.1001/jama.2018.20579


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