MedicalResearch.com Interview with:
David L. Brown, MD, FACC
Professor of Medicine
Washington University School of Medicine
St. Louis, MO 63110
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There is very little high quality data for use of IVC filters in general and no high quality data for using them in the population of patients who have had a DVT or PE and have a contraindication to anticoagulation.
However, this is the patient population for which filters are most commonly placed. Using administrative, observational data, we found that IVC filter placement in this all-comer population was associated with an increased risk of 30-day mortality after adjusting for baseline differences and immortal time bias.
MedicalResearch.com: What should readers take away from your report?
Response: The main take-home message is that we need randomized trials of IVC filters in patients with a contraindication to anticoagulation and a DVT or PE. These devices come with significant risk and cost and we need better data to justify their use.
Turner TE, Saeed MJ, Novak E, Brown DL. Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality. JAMA Network Open. 2018;1(3):e180452. doi:10.1001/jamanetworkopen.2018.0452
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