Prof. Lawrence Steinman MD Zimmermann Professor of Neurology & Neurological Sciences, and Pediatrics Beckman Center for Molecular Medicine Stanford University Stanford, CA

Multiple Sclerosis: Decrease in Relapses and Brain Lesions with Ublituximab, Targeting B Cells

MedicalResearch.com Interview with:

Prof. Lawrence Steinman MD Zimmermann Professor of Neurology & Neurological Sciences, and Pediatrics Beckman Center for Molecular Medicine Stanford University Stanford, CA

Prof. Steinman

Prof. Lawrence Steinman MD
Zimmermann Professor of Neurology & Neurological Sciences, and Pediatrics
Beckman Center for Molecular Medicine Stanford University
Stanford, CA

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: We are publishing the results of two successful phase 3 trials in relapsing MS (multiple sclerosis).
We tested a glycoengineered antibody to B cells. The glycoengineered antibody are more potent in killing the target. They can be delivered more easily.

MedicalResearch.com: What should readers take away from your report?

Response: The reduction in relapses was better than any reported by other anti-CD20 antibodies.  A barrier of 0.1 relapses per year had never been broken.  Here in both trials the results showed fewer than 0.1 relapse per year, or in other words. less than one relpase in 10 years.

MedicalResearch.com: What recommendations do you have for future research as a results of this study?

Response:  Since multiple sclerosis is triggered by an infection in B cells, combining antibodies that kill the infected cells with an anti-viral might be worthwhile to test.

MedicalResearch.com: Is there anything else you would like to add? Any disclosures?

Response: We also saw a statistically significant increase in disability improvement in these trials.

Citation:

Ublituximab versus Teriflunomide in Relapsing Multiple Sclerosis Lawrence Steinman, M.D., Edward Fox, M.D., Ph.D., Hans-Peter Hartung, M.D., Enrique Alvarez, M.D., Ph.D., Peiqing Qian, M.D., Sibyl Wray, M.D., Derrick Robertson, M.D., DeRen Huang, M.D., Ph.D., Krzysztof Selmaj, M.D., Ph.D., Daniel Wynn, M.D., Gary Cutter, Ph.D., Koby Mok, Ph.D., Yanzhi Hsu, Ph.D., Yihuan Xu, Ph.D., Michael S. Weiss, J.D., Jenna A. Bosco, B.S., Sean A. Power, B.S., Lily Lee, Ph.D., Hari P. Miskin, M.Sc., and Bruce A.C. Cree, M.D., Ph.D., for the ULTIMATE I and ULTIMATE II Investigators*

N Engl J Med 2022;387:704-14. DOI: 10.1056/NEJMoa2201904

https://www.nejm.org/doi/full/10.1056/NEJMoa2201904

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