Multiple Sclerosis: Elevated IgG Linked to Risk of More Severe Disease

MedicalResearch.com Interview with:

Prof. Bernhard Hemmer MD PhDDirector of the Neurology ClinicTechnische Universität München

Prof. Hemmer

Prof. Bernhard Hemmer MD PhD
Director of the Neurology Clinic
Technische Universität München 

MedicalResearch.com: What is the background for this study? What are the main findings? 

Response: The course of multiple sclerosis (MS) is still highly unpredictable and reliable markers to predict disability progression are largely missing. We found that patients with a high IgG Index, which means that the produce large amount of IgG within the CNS, have a higher risk of disease worsening during the first 4 years. I would consider patients with an elevated IgG index at a higher risk to run a more severe disease course. The marker could be used together with others to guide treatment decisions after multiple sclerosis diagnosis.

MedicalResearch.com: What should readers take away from your report?

Response: Perform a spinal tap during the diagnostic work up in multiple sclerosis . CSF findings help to exclude differential diagnoses, increase diagnostic accuracy and may help allow better prediction of prognosis. Should be done in every patient 

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: We need long term prospective studies to demonstrate that the marker has a predictive value for long term outcome. It would also be important understand the pathomechanistic link between intrathecal IgG synthesis and disease worsening.

No relevant disclosure 

Citation:

Gasperi C, Salmen A, Antony G, et al. Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis. JAMA Neurol. Published online April 29, 2019. doi:10.1001/jamaneurol.2019.0905

Apr 30, 2019 @ 11:52 am

 

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