26 Nov Novel Use of Tazarotene Gel To Treat Acne Scarring
MedicalResearch.com Interview with:
Dr Tarun Narang MD MNAMS
Department of Dermatology, Venereology, and Leprology
Postgraduate Institute of Medical Education and Research
MedicalResearch.com: What is the background for this study?
Response: Acne is one of the most common dermatological problem for which the patients seek medical care. Post acne scarring is a complication of acne, resulting in long lasting physical disfigurement and low self esteem in the affected individuals. Even though there are various methods like microneedling, chemical peeling, cryorolling and ablative lasers to address the post acne atrophic scarring, these procedures are office based hence physician dependent. A home based treatment modality that can treat post acne atrophic scarring with a comparable efficacy to the procedural modalities of treatment will be beneficial to the patient.
Our study was done to assess the efficacy of a topical modality of treatment, tazarotene gel, 0.1% in the management of post acne atrophic scarring in comparison to an established method, the microneedling.
MedicalResearch.com: What are the main findings?
Response: Our study was done in a split face manner to compare the improvement in post acne scarring with either of the two methods in the same patient. A significant improvement in acne scars in quantitative measures was noted with both the methods, which was comparable. Patient satisfaction scores with both the methods were better in patients who had prior exposure to isotretinoin for acne.
MedicalResearch.com: What should readers take away from your report?
Response: The evidence from our study suggests the use of topical tazarotene, 0.1% gel for the management of atrophic post acne scars in routine clinical practice. The comparable efficacy that we have observed with this home based modality to that of office based microneedling procedure may cut down the treatment expense of people with atrophic post acne scars.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Further research with a longer follow up can be done in future. Changes in collagen profile can also be studied to substantiate the study findings. Tazarotene gel and cream has also been found to be useful in treatment of acne, hence studies assessing the effectiveness of tazarotene in preventing scarring by early treatment of active acne can also be undertaken.
Afra TP, Razmi T M, Narang T, Dogra S, Kumar A. Topical Tazarotene Gel, 0.1%, as a Novel Treatment Approach for Atrophic Postacne ScarsA Randomized Active-Controlled Clinical Trial. JAMA Facial Plast Surg.Published online November 15, 2018. doi:10.1001/jamafacial.2018.1404
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