MedicalResearch.com Interview with:
Keshav K. Singh, Ph.D.
Joy and Bill Harbert Endowed Chair in Cancer Genetics
Professor of Genetics, Pathology and Environmental Health
Founding Editor-in-Chief, Mitochondrion Journal
Director, Cancer Genetics Program
The University of Alabama at Birmingham
Birmingham, AL 35294
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Decline in mitochondrial DNA content and mitochondrial function has been observed in aging humans. We created mouse to mimic those condition to show that decline in mitochondrial function leads to development of wrinkles and loss of hair.
The main finding is that by restoring mitochondrial function we can reverse skin wrinkles to normal healthy skin and also regain hair growth.
MedicalResearch.com: What should readers take away from your report?
Response: Protecting mitochondria or rejuvenating your mitochondria can either slow wrinkle formation and loss of hair or eliminate wrinkles and regrow hair.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: We are developing agents which can restore mitochondrial DNA content and function.
MedicalResearch.com: Is there anything else you would like to add?
Response: This phenomenon can be summed up as Kayakalpa. In vedic literature, “Kaya” is described as body and “Kalpa” as transformation. Kaya Kalpa is a set of therapies that can reverse the physical degeneration caused by age. The therapies can transform old cells to new again.Kaya Kalpa is a true science of “rejuvenation”.
No disclosures to make
Bhupendra Singh, Trenton R. Schoeb, Prachi Bajpai, Andrzej Slominski, Keshav K. Singh. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. Cell Death & Disease, 2018; 9 (7) DOI: 1038/s41419-018-0765-9
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