Study Examines Higher Systolic Blood Pressure and Kidney Disease Progression

MedicalResearch.com Interview with:
Dr Will Herrington MD, MRCP and
Dr Natalie Staplin PhD
Nuffield Department of Population Health,
University of Oxford
Oxford, UK

Medical Research: What is the background for this study? What are the main findings?

Response: These analyses use data from SHARP, a trial of 9000 patients with chronic kidney disease which established that lowering LDL-cholesterol with a statin-based regime (simvastatin 20mg/ezetimibe 10mg) safely reduced risk of a heart attack or stroke in kidney patients.

We have now used the SHARP dataset to investigate the association between blood pressure and rate of renal progression among those with different levels of albumin in the urine. These observations show that higher systolic blood pressure is associated with faster rate of renal progression irrespective of the presence or absence of albumin in the urine.

Medical Research: What should clinicians and patients take away from your report?

Response: These results suggest that the higher blood pressure targets among those without albuminuria, which many clinical guidelines recommend, may not be appropriate.

Medical Research: What recommendations do you have for future research as a result of this study?

Response: Large randomized trials of intensive versus standard blood pressure control are indicated (and the renal results from the SPRINT trial are eagerly awaited).

Citation:

Abstract presented at the 2015 ASN

The Relevance of Systolic Blood Pressure to Vascular Disease in Chronic Kidney Disease Patients with and without Vascular Disease: Observations from the Study of Heart and Renal Protection (SHARP) Parminder K. Judge, William G. Herrington. On behalf of the SHARP Collaborative Group. CTSU, Univ of Oxford.

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Dr Will Herrington MD, MRCP and, & Dr Natalie Staplin PhD (2015). Study Examines Higher Systolic Blood Pressure and Kidney Disease Progression m

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