MedicalResearch.com Interview with:
Andrew Blauvelt, M.D., M.B.A.
Oregon Medical Research Center
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This new paper focuses on treatment of psoriasis in classically difficult-to-treat areas of the body, which include the scalp, the palms/soles, and the fingernails.
We show that guselkumab, which is a new biologic therapy that selectively targets IL-23 (a key pro-inflammatory cytokine in psoriasis pathogenesis), works well in these areas affected by psoriasis.
More specifically, after 6 months of treatment with guselkumab, approximately 85%, 80%, and 60% of patients achieved complete or near complete clearance of psoriasis in their scalp, palms/soles, and fingernails, respectively.
MedicalResearch.com: What should readers take away from your report?
Response: These new data will inform therapeutic decisions by clinicians when faced with psoriasis patients with disease in difficult-to-treat areas of the body
Foley P, Gordon K, Griffiths CEM, et al. Efficacy of Guselkumab Compared With Adalimumab and Placebo for Psoriasis in Specific Body RegionsA Secondary Analysis of 2 Randomized Clinical Trials. JAMA Dermatol.Published online May 16, 2018. doi:10.1001/jamadermatol.2018.0793
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