MedicalResearch.com Interview with:
Rick Sumner, PhD, FAAA
The Mary Lou Bell McGrew Presidential Professor for Medical Research
Chair, Department of Cell & Molecular Medicine (formerly, Anatomy and Cell Biology)
Rush University Medical Center
Chicago, IL 60612
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The main cause of failure for total hip replacements is implant loosening which is often a consequence of particle-induced peri-implant osteolysis. Unfortunately, this condition is usually not diagnosed until it has progressed to the point of needing a revision surgery.
We discovered two biomarkers that may be useful for identifying at risk patients much earlier than is currently possible.
MedicalResearch.com: What should readers take away from your report?
Response: Early identification of at-risk patients would alert surgeons to follow these patients more carefully and may suggest novel, non-surgical approaches to therapy.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: The generalizability of the findings needs to be tested by studying additional cohorts of patients.
Disclosures: There is a provisional U.S. patent application on file.
Ryan D. Ross, Youping Deng, Rui Fang, Nicholas B. Frisch, Joshua J. Jacobs, Dale R. Sumner.Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis. Journal of Orthopaedic Research®, 2018; DOI: 1002/jor.24044
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