Urinary Biomarkers Identify Early Problems With Hip Replacements

MedicalResearch.com Interview with:

Rick Sumner, PhD, FAAA The Mary Lou Bell McGrew Presidential Professor for Medical Research Chair, Department of Cell & Molecular Medicine (formerly, Anatomy and Cell Biology) Rush University Medical Center Chicago, IL  60612

Dr. Sumner

Rick Sumner, PhD, FAAA
The Mary Lou Bell McGrew Presidential Professor for Medical Research
Chair, Department of Cell & Molecular Medicine (formerly, Anatomy and Cell Biology)
Rush University Medical Center
Chicago, IL  60612

 

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The main cause of failure for total hip replacements is implant loosening which is often a consequence of particle-induced peri-implant osteolysis. Unfortunately, this condition is usually not diagnosed until it has progressed to the point of needing a revision surgery.

We discovered two biomarkers that may be useful for identifying at risk patients much earlier than is currently possible.

MedicalResearch.com: What should readers take away from your report?

Response: Early identification of at-risk patients would alert surgeons to follow these patients more carefully and may suggest novel, non-surgical approaches to therapy.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: The generalizability of the findings needs to be tested by studying additional cohorts of patients.

Disclosures: There is a provisional U.S. patent application on file.

Citation:
Ryan D. Ross, Youping Deng, Rui Fang, Nicholas B. Frisch, Joshua J. Jacobs, Dale R. Sumner.Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis. Journal of Orthopaedic Research®, 2018; DOI: 1002/jor.24044

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