15 Jun Vaccination Provides Protection Against COVID-19 Severity and Enhances Protection for Those with Prior Infection Against Reinfection With New Variants
MedicalResearch.com Interview with:
Hiam Souheil Chemaitelly Ph.D.
Assistant Professor of Research in Population Health Sciences
Population Health Sciences
Weill Cornell Medical College
MedicalResearch.com: What is the background for this study?
Response: The Omicron BA.1 and BA.2 variants resulted in a large wave of infections. The level of protection provided by prior infection or vaccination with Pfizer and Moderna mRNA vaccines or a combination of both against infection with Omicron BA.1 and BA.2 subvariants was unknown.
MedicalResearch.com: What are the main findings?
Response: The study showed that prior infection combined with three doses of mRNA vaccination was strongly protective against symptomatic Omicron infection and against severe, critical, or fatal COVID-19. Meanwhile, two dose vaccination alone was not associated with significant protection against symptomatic infection. Booster vaccination provided only 60% protection against infection but waned rapidly thereafter. However, vaccination was associated with >70% protection against severe, critical, or fatal COVID-19.
Prior SARS-CoV-2 infection alone was associated with 50% protection against symptomatic Omicron infection, and did not appear to wane even a year after infection.
MedicalResearch.com: What should readers take away from your report?
Response: Vaccination provides protection against COVID-19 severity and enhances protection for those with prior infection against reinfection with new variants.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: The study findings highlight the importance of better understanding the rapid waning in vaccine-induced immunity in contrast to natural immunity and to develop coronavirus vaccines that are broadly protective against different variants with long-lasting protection.
I have no competing interests to declare.
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