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14 May 21-Gene Recurrence Scores of 26 or Higher Can Help Determine If Chemotherapy Will Be Effective

Posted at 15:24h in Author Interviews, Cancer Research, Genetic Research, JAMA by

MedicalResearch.com Interview with:

  • Sung Jun Ma, MD, resident physician in Radiation Medicine at Roswell Park Comprehensive Cancer Center (first author)
  • Oluwadamilola T. Oladeru, MD, a resident physician at Massachusetts General Hospital Cancer Center

MedicalResearch.com: What is the background for this study?

Response: More than 40% of women with hormone receptor-positive, HER2-negative early-stage breast cancer have high recurrence scores (RS) of 26-30. Optimal adjuvant systemic therapy in this subgroup remains unclear, and national guidelines currently recommend either chemoendocrine therapy or endocrine therapy alone. In addition, the difference in overall survival of a patient with a RS 26-30 versus RS >30 is unclear.

MedicalResearch.com: What are the main findings?

Response: Our main findings are:

1) Chemotherapy improves outcomes for those with RS 26-30,

(2) RS >30 carries a worse prognosis for survival compared to RS 26-30 despite receiving chemoendocrine therapy, and

(3) The magnitude of chemotherapy benefit appears to be similar between those with RS 26-30 and RS >30. 

MedicalResearch.com: What should readers take away from your report?

Response: Breast cancer patients with a 21-gene recurrence score of 26 or higher are a heterogeneous group of patients with different prognosis and outcomes, and chemotherapy may benefit patients with recurrence scores of 26-30.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: Further prospective studies are needed to investigate optimal adjuvant therapy regimens for patients with a high 21-gene recurrence score 

No relevant disclosures

 Citation:

Ma SJ, Oladeru OT, Singh AK. Association of Adjuvant Chemotherapy With Overall Survival in Patients With Early-Stage Breast Cancer and 21-Gene Recurrence Scores of 26 or Higher. JAMA Netw Open. 2020;3(5):e203876. doi:10.1001/jamanetworkopen.2020.3876

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2765371

 

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Last Updated on May 14, 2020 by Marie Benz MD FAAD

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