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Bariatric Surgery Linked to Reduced Melanoma Risk

MedicalResearch.com Interview with:
Magdalena Taube, PhD
Institute of Medicine, Dept of Molecular and Clinical Medicine
Sahlgrenska Academy at Gothenburg University
Wallenberg laboratory
Gothenburg Sweden 

MedicalResearch.com: What is the background for this study?

Response: Obesity is a cancer risk factor, and bariatric surgery in patients with obesity is associated with reduced cancer risk. However, evidence of an association among obesity, bariatric surgery and skin cancer is limited.

In this study we used data from the Swedish Obese Subjects (SOS) study– a prospective controlled intervention trial examining bariatric surgery outcomes – to analyze the impact of bariatric surgery on skin cancer incidence.

MedicalResearch.com: What are the main findings?

Response: With a median follow-up time of 18.1 years, we found that bariatric surgery was associated with a markedly reduced risk of skin cancer, including melanoma.

MedicalResearch.com: What should readers take away from your report?

Response: Our findings give additional support for a link between obesity and skin cancer, including melanoma, and for the idea that weight loss reduces cancer incidence. However, bariatric surgery should not be viewed as a public health intervention specific for skin cancer.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: Further research on potential factors that could explain the link between obesity, bariatric surgery and skin cancer is needed. Factors that may affect skin cancer incidence includes changes in life style, eating behavior, gut signaling and altered metabolic/endocrine processes.

Any disclosures?

Co-author Professor Martin Bergö has received speaker fees from Baxter Medical and LEO Pharma.
Co-author Lena MS Carlsson has recieved lecture fees from AstraZeneca, Johnson & Johnson and Merck Sharpe & Dohme.
The other authors declare no conflict of interest.

This study was funded by the NIDDK/NIH, the Swedish Research Council, grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement, and the Swedish Diabetes Foundation.

Citation: 

Taube M, Peltonen M, Sjöholm K, et al. Association of Bariatric Surgery With Skin Cancer Incidence in Adults With ObesityA Nonrandomized Controlled TrialJAMA Dermatol. Published online October 30, 2019. doi:10.1001/jamadermatol.2019.3240

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Oct 30, 2019 @ 9:17 pm 

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