23 Dec Age at Primary Breast Cancer Affects Risk of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Carriers
Dr. Schmidt
MedicalResearch.com Interview with:
Dr. Marjanka Schmidt PhD
Group Leader, Molecular Pathology
Netherlands Cancer Institute
Medical Research: What is the background for this study? What are the main findings?
Dr. Schmidt: BRCA1/2 mutation carriers who developed a primary breast cancer are thought to be at high risk to develop a contralateral breast cancer (breast cancer in the opposite breast). Our study is one of the first to provide unbiased risk estimates for young breast cancer patients with a pathogenic BRCA1/2 mutation. We also showed that age of onset of the first breast cancer is a predictor for the development of contralateral breast cancer in BRCA1/2 mutation carriers, but not in non-carriers.
Medical Research: What should clinicians and patients take away from your report?
Dr. Schmidt: That for risk prediction in BRCA1/2 mutation carriers they should consider age at onset, and that though some breast cancer patients carrying a BRCA1/2 mutation are at relatively high risk of breast cancer, for certain subgroups this risk may not be as high as previously thought.
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Schmidt: It will be important to develop absolute risk curves using prospective data from more recently diagnosed patients for patient counseling, including information about family history of breast cancer.
Citation:
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JCO JCO623942; published online on December 23, 2015;
Dr. Marjanka Schmidt PhD (2015). Age at Primary Breast Cancer Affects Risk of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Carriers
Last Updated on December 23, 2015 by Marie Benz MD FAAD