MedicalResearch.com Interview with:
Sameek Roychowdhury, MD, PhD
Assistant Professor, Internal Medicine, College of Medicine
Assistant Professor, Department of Pharmacology
College of Pharmacy
Department of Internal Medicine
Division of Medical Oncology
Wexner Medical Center
The Ohio State University
Medical Research: What is the background for this study? What are the main findings?
Dr. Roychowdhury: Precision cancer medicine is a new paradigm to match patients to therapies based on the molecular alterations in their cancer. Novel genomic testing of cancer using next generation sequencing can reveal numerous mutations for each patient across many genes and types of cancer, and this requires detailed time-intensive interpretation. Driver mutations can confer a selective growth or survival advantage to cancer cells, while passenger mutations do not.
Cancer Driver Log, or CanDL, is meant to aid interpretation of mutations by providing the latest literature evidence for individual driver mutations, and thereby aiding pathologists, lab directors, and oncologists in interpreting mutations found in their patient’s cancer.
Medical Research: What should clinicians and patients take away from your report?
Dr. Roychowdhury: Cancer Driver Log is a freely available resource connecting driver mutations to the latest literature evidence.
Researchers and clinicians can also directly contribute to the upkeep of CanDL may submitting mutations and providing feedback on the website. (candl.osu.edu)
Medical Research: What recommendations do you have for future research as a result of this study?
Dr. Roychowdhury: Efforts to consolidate identification and curation of clinically relevant mutations in cancer will facilitate implementation of precision cancer medicine for our patients.
Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations
The Journal of Molecular Diagnostics, Volume 17, Issue 5, September 2015, Pages 554-559
Senthilkumar Damodaran, Jharna Miya, Esko Kautto, Eliot Zhu, Eric Samorodnitsky, Jharna Datta, Julie W. Reeser, Sameek
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Sameek Roychowdhury, MD, PhD (2015). Cancer Driver Log Facilitates Precision Medicine, Linking Providers With Genetic Data Bank