Cancer Driver Log Facilitates Precision Medicine, Linking Providers With Genetic Data Bank

Sameek Roychowdhury, MD, PhD Assistant Professor, Internal Medicine, College of Medicine Assistant Professor, Department of Pharmacology, College of Pharmacy Department of Internal Medicine Division of Medical Oncology Wexner Medical Center The Ohio State UniversityMedicalResearch.com Interview with:
Sameek Roychowdhury, MD, PhD
Assistant Professor, Internal Medicine, College of Medicine
Assistant Professor, Department of Pharmacology
College of Pharmacy
Department of Internal Medicine
Division of Medical Oncology
Wexner Medical Center
The Ohio State University

Medical Research: What is the background for this study? What are the main findings?

Dr. Roychowdhury: Precision cancer medicine is a new paradigm to match patients to therapies based on the molecular alterations in their cancer. Novel genomic testing of cancer using next generation sequencing can reveal numerous mutations for each patient across many genes and types of cancer, and this requires detailed time-intensive interpretation. Driver mutations can confer a selective growth or survival advantage to cancer cells, while passenger mutations do not.

Cancer Driver Log, or CanDL, is meant to aid interpretation of mutations by providing the latest literature evidence for individual driver mutations, and thereby aiding pathologists, lab directors, and oncologists in interpreting mutations found in their patient’s cancer.

Medical Research: What should clinicians and patients take away from your report?

Dr. Roychowdhury: Cancer Driver Log is a freely available resource connecting driver mutations to the latest literature evidence.

Researchers and clinicians can also directly contribute to the upkeep of CanDL may submitting mutations and providing feedback on the website. (candl.osu.edu)

Medical Research: What recommendations do you have for future research as a result of this study?

Dr. Roychowdhury: Efforts to consolidate identification and curation of clinically relevant mutations in cancer will facilitate implementation of precision cancer medicine for our patients.

Citation:

Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations

The Journal of Molecular Diagnostics, Volume 17, Issue 5, September 2015, Pages 554-559

Senthilkumar Damodaran, Jharna Miya, Esko Kautto, Eliot Zhu, Eric Samorodnitsky, Jharna Datta, Julie W. Reeser, Sameek

MedicalResearch.com is not a forum for the exchange of personal medical information, advice or the promotion of self-destructive behavior (e.g., eating disorders, suicide). While you may freely discuss your troubles, you should not look to the Website for information or advice on such topics. Instead, we recommend that you talk in person with a trusted medical professional.

The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

 

Sameek Roychowdhury, MD, PhD (2015). Cancer Driver Log Facilitates Precision Medicine, Linking Providers With Genetic Data Bank 

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.