23 Aug Checkpoint Inhibitors’ Adverse Events Linked to Tumor Mutational Burden
MedicalResearch.com Interview with:
Prof. Dr. Lukas Flatz MD
Institute of Immunobiology
Kantonsspital St Gallen, St Gallen
MedicalResearch.com: What is the background for this study?
Response: Toxicity is an important limiting factor of treatment with checkpoint inhibitors. We aimed in investigating the relationship between immune-related adverse events during anti-PD-1 therapy and tumor mutational burden by comparing large scale surveillance data of irAEs with the median tumor mutational burden across multiple cancer types.
MedicalResearch.com: What should readers take away from your report?
Response: Our study shows that a high tumor mutational burden is associated with a higher risk to develop toxicity during treatment. Our data suggest that a patient suffering from a tumor with a high tumor mutational burden is regularly followed-up for the development of toxicity during the treatment. The tumor mutational burden may help the treating doctor to estimate the risk for developing toxicity during treatment.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: While our publication shows an association between tumor mutational burden and immune-related adverse event we do not yet understand the exact underlying mechanism. Our laboratory team (see www.flatzlab.com) is currently using a prospective cohort to decipher the underlying mechanisms.
See the disclosures in the publication.
Bomze D, Hasan Ali O, Bate A, Flatz L. Association Between Immune-Related Adverse Events During Anti–PD-1 Therapy and Tumor Mutational Burden. JAMA Oncol. Published online August 22, 2019. doi:10.1001/jamaoncol.2019.3221
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