21 Dec GERD Associated With Increased Risk of Malignancy of the Upper Aerodigestive Tract
MedicalResearch.com Interview with:
Dr. Edward D. McCoul, MD, MPH
Ochsner Medical Center
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Population-level data suggests a link between gastroesophageal reflux disease and cancer of the throat and sinuses in adults over 65 years of age. T
he strength of association between reflux and cancer is strongest for anatomic sites closest to the esophagus, where acid and other stomach contents may have the greatest exposure.
MedicalResearch.com: What should clinicians and patients take away from your report?
Response: It is important to point out that a causative link cannot be established from this type of data.
It is unclear what effect acid exposure may have on tumor development, although chronic inflammation is a possibility.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Further research should focus on assessing these associations in a younger population and investigating mechanisms of causation.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Charles A. Riley, Eric L. Wu, Mei-Chin Hsieh, Michael J. Marino, Xiao-Cheng Wu, Edward D. McCoul. Association of Gastroesophageal Reflux With Malignancy of the Upper Aerodigestive Tract in Elderly Patients. JAMA Otolaryngol Head Neck Surg. Published online December 21, 2017. doi:10.1001/jamaoto.2017.2561
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