MedicalResearch.com Interview with:
Clive S. Zent MD
Professor of Medicine
Director of Lymphoma/CLL Program
Wilmot Cancer Institute
University of Rochester Medical Center
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) have an increased risk of all skin cancers including malignant melanoma.
This study in a stable population of CLL patients managed by a regional referral center confirmed that melanoma was over 6 times more common in than in an age and sexed matched general population. Because of the proactive skin screening program at the University of Rochester Medical Center’s Wilmot Cancer Center, most melanomas (77%) were detected at earlier stages and were treated surgically with curative intent. One patient with CLL and metastatic melanoma had a sustained remission of both diseases on treatment with ibrutinib and pembrolizumab.MedicalResearch.com: What should readers take away from your report?
Response: Patients with CLL should be actively monitored for skin cancers with regular self-examinations and dermatology follow up. Early detection of melanoma can result in curative management.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Determine the causes for increased risk of skin cancer in patients with CLL.
William J. Archibald, Philip J. Meacham, AnnaLynn M. Williams, Andrea M. Baran, Adrienne I. Victor, Paul M. Barr, Deepak M. Sahasrahbudhe, Clive S. Zent. Management of melanoma in patients with chronic lymphocytic leukemia. Leukemia Research, 2018; 71: 43 DOI: 10.1016/j.leukres.2018.07.003
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