Lung Cancer: Breath Test Detection

Dr. Peter Mazzone MD, MPH Pulmonary, Allergy and Critical Care Medicine Cleveland Clinic Main Campus Cleveland, OH 44195MedicalResearch.com Interview with:
Dr. Peter Mazzone MD, MPH
Pulmonary, Allergy and Critical Care Medicine
Cleveland Clinic Main Campus
Cleveland, OH 44195

MedicalResearch.com: What are the main findings of this study?

Dr. Mazzone: There were 2 parts to this study:

In the first part we looked at how the breath collection instrument and sensor were performing and made adjustments to both in order to optimize its performance. In the second part we used the improved device and sensor to see if we could accurately separate a sensor signal of our patients with lung cancer from those without lung cancer. We found good separation of lung cancer from non-cancer breath signals, and very good separation of signals of one type of lung cancer from another.

We have concluded that a colorimetric sensor array based breath test is capable of separating those with lung cancer from those without.

We learned about ways that we can enhance the sensor and breath collection instrument, and showed enough promise that this can be an accurate test, that we plan to design a larger study with an improved system in hopes that this will be the final step towards having a clinically useful test.

Citation:

The Analysis of Volatile Organic Compound Profiles in the Breath as a Biomarker of Lung Cancer

Peter Mazzone, MD; Xiaofeng Wang, PhD; Paul Rhodes, PhD; Ray Martino, PhD; Sung Lim, PhD; Mary Beukeman; Meredith Seeley; Humberto Choi, MD; James Jett, MD

Chest. 2013;144(4_MeetingAbstracts):645A. doi:10.1378/chest.1703380

 

 
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