Alex Spira, MD, PhD, FACP Medical Oncologist Virginia Cancer Specialists and Chair of the US Oncology Research Executive Committee

PROBODY Technology Allows Chemo To Be Used Just At Tumor Site, Limiting Side Effects

MedicalResearch.com Interview with:

Alex Spira, MD, PhD, FACP Medical Oncologist Virginia Cancer Specialists and Chair of the US Oncology Research Executive Committee

Dr. Spira

Alex Spira, MD, PhD, FACP
Medical Oncologist
Virginia Cancer Specialists and
Chair of the US Oncology Research Executive Committee

MedicalResearch.com: What is the background for this study? Would you explain what the conjugate consists of and what types of cancer it may target? What are the main findings?

Response: The concept of the CX072 and CX2029 studies is that they use what’s called a probody molecule that gets broken down only at the tumor site. This is completely novel in that it helps diminish toxicity by not having less systemic absorption. In the case of CX2029, this target was previously undruggable, meaning the systemic toxicity was too high. By limiting it to activity at the tumor, that is significantly abated.  

MedicalResearch.com: What are the main findings?

Response: The study is interesting because, especially in the case of CX2029, expansion cohorts are opening where activity has been seen. It’s also unique because you can apply this technology to virtually any antibody, meaning it’s a chance to diminish toxicity and improve efficacy. 

No disclosures.

Citation:

CX-2029, a PROBODY drug conjugate targeting CD71 (transferrin receptor): Results from a first-in-human study (PROCLAIM-CX-2029) in patients (Pts) with advanced cancer.

Melissa Lynne Johnson, Anthony B. El-Khoueiry, Navid Hafez, Nehal J. Lakhani, Hirva Mamdani, Jordi Rodon Ahnert, Rachel E. Sanborn, Thang Ho, Rachel Li, Jana Waldes, and Alexander I. Spira

Journal of Clinical Oncology 2020 38:15_suppl, 3502-3502

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Last Modified: Jun 12, 2020 @ 9:56 am 

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