Androgen Deprivation Therapy For Prostate Cancer May Not Be Prudent In Men With Heart Attack History

Anthony V. D'Amico, MD, PhD Chief, Division of Genitourinary Radiation Oncology Professor of Radiation Oncology, Harvard Medical SchoolMedicalResearch.com Interview with:
Anthony V. D’Amico, MD, PhD
Chief, Division of Genitourinary Radiation Oncology
Professor of Radiation Oncology, Harvard Medical School

Medical Research: What is the background for this study? What are the main findings?

Dr. D’Amico: Controversy exists as to whether androgen deprivation therapy (ADT) used to treat prostate cancer can cause fatal cardiac events.

We found that in men with moderate to severe comorbidity based most often on a history of a heart attack that the use of 6 months of androgen deprivation therapy to treat non metastatic but clinically significant prostate cancer was associated with both an increased risk of a fatal heart attack and shortened survival.

Medical Research: What should clinicians and patients take away from your report? Medical Research: What recommendations do you have for future research as a result of this study? 

Dr. D’Amico: Therefore the use of  androgen deprivation therapy to treat prostate cancer in these men should be carefully considered and efforts to ensure that heart function is being optimally managed before initiating  androgen deprivation therapy would be prudent.

Citation:

Anthony V. D’Amico, Ming-Hui Chen, Andrew Renshaw, Marian Loffredo, Philip W. Kantoff. Long-term Follow-up of a Randomized Trial of Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer. JAMA, 2015; 314 (12): 1291 DOI:10.1001/jama.2015.8577

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Anthony V. D’Amico, MD, PhD (2015). Androgen Deprivation Therapy For Prostate Cancer May Not Be Prudent In Men With Heart Attack History

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