Medical Research: What is the background for this study? What are the main findings?
Dr. D’Amico: Controversy exists as to whether androgen deprivation therapy (ADT) used to treat prostate cancer can cause fatal cardiac events.
We found that in men with moderate to severe comorbidity based most often on a history of a heart attack that the use of 6 months of androgen deprivation therapy to treat non metastatic but clinically significant prostate cancer was associated with both an increased risk of a fatal heart attack and shortened survival.
Medical Research: What should clinicians and patients take away from your report? Medical Research: What recommendations do you have for future research as a result of this study?
Dr. D’Amico: Therefore the use of androgen deprivation therapy to treat prostate cancer in these men should be carefully considered and efforts to ensure that heart function is being optimally managed before initiating androgen deprivation therapy would be prudent.
Anthony V. D’Amico, Ming-Hui Chen, Andrew Renshaw, Marian Loffredo, Philip W. Kantoff. Long-term Follow-up of a Randomized Trial of Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer. JAMA, 2015; 314 (12): 1291 DOI:10.1001/jama.2015.8577
MedicalResearch.com is not a forum for the exchange of personal medical information, advice or the promotion of self-destructive behavior (e.g., eating disorders, suicide). While you may freely discuss your troubles, you should not look to the Website for information or advice on such topics. Instead, we recommend that you talk in person with a trusted medical professional.
The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.
Anthony V. D’Amico, MD, PhD (2015). Androgen Deprivation Therapy For Prostate Cancer May Not Be Prudent In Men With Heart Attack History