Prostate Cancer: No Association Between Androgen Deprivation Therapy and Dementia Interview with:
Farzin Khosrow-Khavar, M.Sc. Ph.D. Candidate
Department of Epidemiology, Biostatistics and Occupational Health, McGill University
Center for Clinical Epidemiology – Jewish General Hospital
Montreal, QC What is the background for this study? What are the main findings?

Response: Previous studies have shown an association between androgen deprivation therapy (ADT) and risk of dementia and Alzheimer’s disease. However, these studies had methodological limitations that may account for this positive association. Using appropriate study design and methodology, we found no association between androgen deprivation therapy and risk of dementia (including Alzheimer’s disease) in patients with prostate cancer. These results were consistent by cumulative duration of  androgen deprivation therapy use and by ADT modality. What should readers take away from your report?

Response: This study shows that there is no association between androgen deprivation therapy and dementia in patients with prostate cancer. Thus, this study provides reassurance to patients with prostate cancer regarding this potential adverse event. What recommendations do you have for future research as a result of this study?

Response: Patients who are diagnosed with prostate cancer are an older patient population and thus at increased risk of dementia. This study should provide these patients with reassurance that  androgen deprivation therapy does not cause dementia. Additional studies in different settings are needed to confirm these findings. 

No disclosures. Thank you for your contribution to the community.


J Clin Oncol. 2017 Jan 10;35(2):201-207. Epub 2016 Nov 21.
Androgen Deprivation Therapy and the Risk of Dementia in Patients With Prostate Cancer.
Khosrow-Khavar F1, Rej S1, Yin H1, Aprikian A1, Azoulay L1.

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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Last Updated on February 27, 2017 by Marie Benz MD FAAD