PSMA PET/CT Can Map Prostate Cancer Recurrences With Very Low PSA Levels

MedicalResearch.com Interview with:
Jeremie Calais PhD Ahmanson Translational Imaging Division UCLA Nuclear Medicine Department Los Angeles, CA 90095Jeremie Calais MD

Ahmanson Translational Imaging Division
UCLA Nuclear Medicine Department
Los Angeles, CA 90095

 MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The only curative treatment for recurrent prostate cancer after radical prostatectomy is salvage radiotherapy. Unfortunately, current standard imaging modalities are too insensitive to visualize the location of the recurrence until it is too late. As a result, salvage radiotherapy is directed to areas only suspected to harbor the recurrence based upon a “best guess” approach according to standard guidelines that define radiotherapy treatment volumes.

PSMA PET/CT is a new imaging technique with sensitivity sufficient to detect and localize the recurrent prostate cancer early enough to potentially guide salvage radiotherapy.

The first sign of prostate cancer recurrence is a rising PSA. For salvage radiotherapy to be successful, it should be initiated before the PSA rises above 1 ng/mL, and ideally, closer to 0.2 ng/mL or lower. PSMA PET/CT localizes sites of prostate cancer recurrence in up to 70% of patients with low PSA, below < 1.0.

In the US it is not yet FDA approved and currently only used for research purposes. In our current study we included 270 patients with early recurrence of prostate cancer after surgery from Germany and UCLA,  we found that 20 % of the patients had at least one lesion detected by  PSMA PET/CT which was NOT covered by the standard radiation fields. Obviously, salvage radiotherapy is only curative if recurrent disease is completely encompassed by the radiotherapy fields and would have failed in these patients.

MedicalResearch.com: What should readers take away from your report?

Response: PSMA PET/CT can have a significant major impact in 20% of patients with early biochemical recurrence (still curable) by showing lesions outside the standard radiation fields and therefore by changing the plans of the radiation fields.

More generally, the results of this study represent one more step towards the integration of PET/CT molecular imaging into true precision individualized radiation therapy.

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: We believe that PSMA PET/CT will be ultimately incorporated into the standard of care of patients with prostate cancer. Every patient with prostate cancer should get a PSMA PET/CT before radiation therapy in order to get accurate staging and precise estimation of the localization of the disease.

MedicalResearch.com: Is there anything else you would like to add?

Response: Please see the following link

http://www.snmmi.org/NewsPublications/NewsDetail.aspx?ItemNumber=25910

Citations:

Jeremie Calais, Johannes Czernin, Minsong Cao, Amar U. Kishan, John V. Hegde, Narek Shaverdian, Kiri Sandler, Fang-I Chu, Chris R. King, Michael L. Steinberg, Isabel Rauscher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P. Fendler, Matthias Eiber, and Nicholas G. Nickols

68Ga-PSMA-11 PET/CT Mapping of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy in 270 Patients with a PSA Level of Less Than 1.0 ng/mL: Impact on Salvage Radiotherapy PlanningJ Nucl Med 2018 59:230-237 published ahead of print November 9, 2017(10.2967/jnumed.117.201749).

 

 

The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

 

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.