MedicalResearch.com Interview with:
Amar U. Kishan, MD
Department of Radiation Oncology
University of California, Los Angeles
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Typical external beam radiation courses range up to 8-9 weeks in length (39-45 treatments). There are data that shorter courses, delivering a higher dose per day, may be just as effective.
Stereotactic body radiotherapy (SBRT) really pushes this concept by condensing the treatment to just four to five treatments, with a high dose per day.
Here, we present the pooled results of the outcomes of 2142 men with low and intermediate risk prostate cancer and a median of 6.9 years of followup.
We demonstrate a very favorable efficacy and safety profile. Specifically, the rates of recurrences were 4.5% and 10.2% for low and intermediate risk disease at 7 years, and rates of late severe toxicity were 2.4% for urinary toxicity and 0.4% for gastrointestinal toxicity.
MedicalResearch.com: What should readers take away from your report?
Response: SBRT is a safe and effective treatment for low- and intermediate-risk prostate cancer. This suggests that it should be a standard of care option for patients. However, considerable care must be taken to do it safely (i.e., rigorous quality assurance, image guidance, etc.).
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: SBRT is already being studied in randomized trials to establish that it should be the standard of care (singular) in low/intermediate risk disease. Interesting avenues of research involve examining SBRT in high-risk prostate cancer and in the postoperative setting.
Disclosures: I have received honoraria from Varian Medical Systems, Inc. and ViewRay, Inc. I have served on and Advisory Board for Janssen.
Kishan AU, Dang A, Katz AJ, et al. Long-term Outcomes of Stereotactic Body Radiotherapy for Low-Risk and Intermediate-Risk Prostate Cancer. JAMA Netw Open. 2019;2(2):e188006. doi:10.1001/jamanetworkopen.2018.8006
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