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20 Jun World Trade Center 9/11 Dust: Altered Gene Expression Links Exposure to Prostate Cancer Risk

Posted at 11:43h in Author Interviews, Environmental Risks, Genetic Research, Prostate Cancer by

MedicalResearch.com Interview with:

Emanuela Taioli, MD, PhD, Director of the Institute for Translational Epidemiology Icahn School of Medicine at Mount Sinai Asociate director for Population Science Tisch Cancer Institute

Dr. Taioli

Emanuela Taioli, MD, PhD,
Director of the Institute for Translational Epidemiology
Icahn School of Medicine at Mount Sinai
Asociate director for Population Science
Tisch Cancer Institute 

MedicalResearch.com: What is the background for this study? What are the main findings? 

Response: An excess incidence of prostate cancer has been identified among World Trade Center responders. We wanted to study if this excess was associated with exposure to WTC dust
The results suggest that respiratory exposure to WTC dust can induce inflammatory and immune responses in prostate tissue. Chronic inflammation could facilitate prostate cancer development

Taken together, our results suggest that World Trade Center prostate cancer cases have a distinct gene expression pattern that may be the result of exposure to specific carcinogens during the WTC attacks. WTC dust-exposed rat prostate displayed unique changes in gene expression and immune cell infiltrates after acute dust exposure, suggesting that the effect of exposure may be measured locally in target organs such as prostate. In addition, some of the genes overexpressed in rat normal prostates as a consequence of exposure are also overexpressed in human prostate cancer tissues, suggesting a link between exposure, local immune dysregulation, and prostate cancer development

MedicalResearch.com: What should readers take away from your report?

Response: Our results provide first line of evidence to support the hypothesis that acute World Trade Center dust exposure through inhalation can profoundly disturb gene expression and immune cell infiltration in the prostate. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: An interesting question remains about the retention and elimination rates of World Trade Center dust particles and their distribution amongst different organs. The long–lasting inflammatory effect in prostate revealed by our study calls for further study of the exposure effect in other organs such as kidney, thyroid, the central nervous system. 

Citation:

Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
Yixuan Gong, Li Wang, Haocheng Yu, Naomi Alpert, Mitchell D. Cohen, Colette Prophete, Lori Horton, Maureen Sisco, Sung-Hyun Park, Hyun-Wook Lee, Judith Zelikoff, Lung-Chi Chen, Mayte Suarez-Farinas, Michael J. Donovan, Stuart A. Aaronson, Matthew Galsky, Jun Zhu, Emanuela Taioli and William K. Oh
Mol Cancer Res June 20 2019 DOI:10.1158/1541-7786.MCR-19-0115

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Last Updated on June 20, 2019 by Marie Benz MD FAAD

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