14 Aug Simple Scoring System Stratifies Colon Cancer Risk in Adults
MedicalResearch.com Interview with:
Thomas F. Imperiale, MD
Indiana University Medical Center
Indianapolis, IN 46202
Medical Research: What is the background for this study?
Dr. Imperiale: The background is that colorectal cancer (CRC) screening is effective and cost-effective, but it is underutilized (35% of eligible persons in the U.S. are not current with screening; 28% have never been screened) and inefficient (persons at low risk have colonoscopy; persons at high risk have stool blood testing or nothing). We know about several risk factors for colorectal cancer and advanced, precancerous polyps. We wanted to see how those factors perform together in stratifying (or separating) risk among the 85% of the U.S. population that is considered to be “average-risk”.
Medical Research: What are the main findings?
Dr. Imperiale: We found that age, sex, whether a first-degree relative has or had colorectal cancer, cigarette smoking, and waist circumference do a good job in separating risk into the 4 categories described in the paper. When tested in the validation subgroup, the risk estimates reproduced themselves fairly well.
Medical Research: What should clinicians and patients take away from your report?
Dr. Imperiale: It is possible to estimate current risk for advanced colorectal neoplasia using reliable and easily-obtained patient-specific factors. These factors do a pretty good job in stratifying risk into one of the four categories. Based on these categories, patients may consider screening tests that are less invasive than colonoscopy or may see that their risk is high, suggesting that a colonoscopy is warranted.
Medical Research: What recommendations do you have for future research as a result of this study?
- Determine the reproducibility of these findings in a separate study sample.
- Determine whether and to what extent the scoring system affects the uptake of screening and choice of screening test.
MedicalResearch.com is not a forum for the exchange of personal medical information, advice or the promotion of self-destructive behavior (e.g., eating disorders, suicide). While you may freely discuss your troubles, you should not look to the Website for information or advice on such topics. Instead, we recommend that you talk in person with a trusted medical professional.
The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.
Thomas F. Imperiale, MD (2015). Simple Scoring System Stratifies Colon Cancer Risk in Adults