15 Jan Increase Risk of Blistering Disorder with Diabetes Medication
MedicalResearch.com Interview with:
Dong Hyun Kim M.D.
Department of Dermatology
CHA Bundang Medical Center
CHA University School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: As a dermatologist, we see many patients with newly diagnosed with bullous pemphigoid (BP), many of whom have diabetes.
The use of DPP-4 inhibitors is a common treatment for diabetes, we have noted previous case reports that DPP-4 inhibitors may be the cause of BP. For this reason, we started this study.
The most important thing in my article is DPP-4 inhibitors, particularly vildagliptin, may be associated with the development of bullous pemphigoid in male patients with diabetes. We have confirmed these points based on the nationwide, population-based study. It is very meaningful because there have been few studies using large sample sizes so far.
MedicalResearch.com: What should readers take away from your report?
Response: Practitioners should consider that DPP-4 inhibitors may be associated with the development of bullous pemphigoid in patients with diabetes. Especially, vildagliptin is a high-risk medication for the development of bullous pemphigoid in male diabetic patients. If BP occurs in patients with diabetes, vildagliptin should be considered as the possible cause.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: It would be meaningful to do further research on why DPP-4 inhibitors make new antigenicity and why vildagliptin is a high-risk medication for development of bullous pemphigoid among all DPP-4 inhibitors. The mechanism and reason is not clear at present.
MedicalResearch.com: Is there anything else you would like to add?
Response: In our study, we could not confirm the actual onset of BP symptoms and the duration of the use of DPP-4 inhibitors before the onset of BP. Further studies are also needed to confirm whether BP symptoms improve when DPP-4 inhibitors are discontinued. In this respect, we are planning additional researches on this point.
Lee SG, Lee HJ, Yoon MS, Kim DH. Association of Dipeptidyl Peptidase 4 Inhibitor Use With Risk of Bullous Pemphigoid in Patients With Diabetes. JAMA Dermatol. Published online January 09, 2019. doi:10.1001/jamadermatol.2018.4556
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