18 Oct Oral Semaglutide As Effective As Injectable In Reducing A1C and Weight Loss
MedicalResearch.com Interview with:
Melanie J Davies CBE MB ChB MD FRCP FRCGP
Professor of Diabetes Medicine
NIHR Senior Investigator Emeritus
Diabetes Research Centre
Leicester Diabetes Centre – Bloom
University of Leicester
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This was the first study to test the effectiveness of an oral GLP-1 in patients with type 2 diabetes.
The main findings were that compared to both placebo and a GLP-1, Semaglutide, delivered by sub-cutaneous injection weekly, the oral therapy delivered once a day produced better results than placebo and similar results to injectable GLP-1 with regard to reductions in HbA1c and weight loss.
MedicalResearch.com: What should clinicians and patients take away from your report?
Response: Readers should take away that this study provides good evidence that delivering GLP-1 therapy orally rather than by injectable therapy may be realized.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: At this stage two studies supported the company Novo Nordisk exploring further the potential for oral Semaglutide with a series of phase 3 studies which are now underway/
Disclosures: Professor Melanie Davies has acted as consultant, advisory board member and speaker for Novo Nordisk, Sanofi-Aventis, Lilly, Merck Sharp & Dohme, Boehringer Ingelheim, AstraZeneca and Janssen, an advisory board member for Servier and as a speaker for Mitsubishi Tanabe Pharma Corporation and Takeda Pharmaceuticals International Inc.
She has received grants in support of investigator and investigator initiated trials from Novo Nordisk, Sanofi-Aventis, Lilly, Boehringer Ingelheim and Janssen.
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Davies M, Pieber TR, Hartoft-Nielsen M, Hansen OKH, Jabbour S, Rosenstock J. Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 DiabetesA Randomized Clinical Trial. JAMA. 2017;318(15):1460–1470. doi:10.1001/jama.2017.14752
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