03 Sep Risk of Type 2 Diabetes Elevated in Women With PCOS – Polycystic Ovary Syndrome
MedicalResearch.com Interview with:
Overlæge, ph.d, dr.med
Endokrinologisk Afdeling M
MedicalResearch.com: What is the background for this study?
Response: Polycystic ovary syndrome (PCOS) is a common endocrine disorder. PCOS is most often defined according to the Rotterdam criteria, which include irregular ovulation, biochemical/clinical hyperandrogenism, and/or polycystic ovaries when other etiologies are excluded. PCOS is associated with insulin resistance and obesity, but data regarding development and risk factors for type 2 diabetes (T2D) in PCOS are limited.
We performed a National Register-based study on Danish women with PCOS and included data regarding T2D events according to diagnosis codes and filled medicine prescriptions (N=18,477). Three age-matched controls were included per patient (N=54,680).
MedicalResearch.com: What are the main findings?
Response: We found that the risk for development of type 2 diabetes was 4 times increased in women with PCOS compared to controls. The median age at diagnosis of type 2 diabetes was 31 years in women with PCOS compared with 35 years in controls suggesting that T2D was diagnosed 4 years earlier in PCOS. Increasing body mass index was associated with increased risk of development of T2D, whereas higher number of births was negatively associated with development of type 2 diabetes.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Further studies are needed regarding predictors of type 2 diabetes in PCOS. Our data support a considerable increased risk for type 2 diabetes in obese women with PCOS.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome
Katrine Hass Rubin Dorte Glintborg Mads Nybo Bo AbrahamsenMarianne Andersen
The Journal of Clinical Endocrinology & Metabolism, jc.2017-01354,https://doi.org/10.1210/jc.2017-01354
Published: 29 August 2017
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