Serum C-peptide levels and risk of death among adults without diabetes mellitus

MedicalResearch.com: Dr. Kyoung-bok Min
Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Republic of Korea

MedicalResearch.com: What are the main findings of the study?

Answer: The aim of this study was to investigate the prospective association of serum C-peptide with all-cause, cardiovascular disease, and coronary heart disease mortality in a non-diabetic population. We also estimated the observed mortality as C-peptide increased across the strata of glycated hemoglobin and fasting blood glucose. We found a linear association between serum C-peptide levels and death from all-cause and cause-specific mortality among adults without non-diabetes mellitus at baseline. Our finding suggests that elevated C-peptide levels may be a marker of subsequent mortality in non-diabetic subjects.

MedicalResearch.com: Were any of the findings unexpected?

Answer:There were no unexpected findings in this study.

MedicalResearch.com: What should clinicians and patients take away from your report?

Answer: We found an association between serum C-peptide levels and all-cause and cause-specific mortality among adults without diabetes at baseline. Our finding suggests that elevated C-peptide levels may be a predictor of future death event with specific cause (cardiovascular disease, ischemic heart disease).

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Answer: Important limitations of this study include a single measurement of serum C-peptide at baseline and the long interval between the measurement and follow-up period. For more precise result, we suggest future studies which will measure C-peptide repeatedly with several years’ interval during follow-up.

Citation:

Serum C-peptide levels and risk of death among adults without diabetes mellitus
Min JY, Min KB.
CMAJ. 2013 Apr 15. [Epub ahead of print] PMID: 23589428

 

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