02 May Serum C-peptide levels and risk of death among adults without diabetes mellitus
MedicalResearch.com: Dr. Kyoung-bok Min
Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Republic of Korea
MedicalResearch.com: What are the main findings of the study?
Answer: The aim of this study was to investigate the prospective association of serum C-peptide with all-cause, cardiovascular disease, and coronary heart disease mortality in a non-diabetic population. We also estimated the observed mortality as C-peptide increased across the strata of glycated hemoglobin and fasting blood glucose. We found a linear association between serum C-peptide levels and death from all-cause and cause-specific mortality among adults without non-diabetes mellitus at baseline. Our finding suggests that elevated C-peptide levels may be a marker of subsequent mortality in non-diabetic subjects.
MedicalResearch.com: Were any of the findings unexpected?
Answer:There were no unexpected findings in this study.
MedicalResearch.com: What should clinicians and patients take away from your report?
Answer: We found an association between serum C-peptide levels and all-cause and cause-specific mortality among adults without diabetes at baseline. Our finding suggests that elevated C-peptide levels may be a predictor of future death event with specific cause (cardiovascular disease, ischemic heart disease).
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Answer: Important limitations of this study include a single measurement of serum C-peptide at baseline and the long interval between the measurement and follow-up period. For more precise result, we suggest future studies which will measure C-peptide repeatedly with several years’ interval during follow-up.
Serum C-peptide levels and risk of death among adults without diabetes mellitus
Min JY, Min KB.
CMAJ. 2013 Apr 15. [Epub ahead of print] PMID: 23589428