14 Apr Study finds COVID-19, Type 2 Diabetes Share Disease Pathways
MedicalResearch.com Interview with:
Daniel J. Drucker, M.D.
Mount Sinai Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This review was prompted by shared mechanistic pathways linking actions of molecules such as ACE2 and DPP4, which are important enzymes with cardiometabolic actions, yet also function as coronavirus receptors. The recognition that people with diabetes and obesity are more prone to severe infection also highlights the importance of understanding the biology
We highlight the intersection of pathways shared by coronavirus infection, and how these might impact our understanding of diabetes and its therapies.
MedicalResearch.com: What should readers take away from your report?
Response: People with diabetes and obesity have higher rates of hospitalization and more severe clinical illness with SARS-CoV-2 coronavirus infection. There are likely adjustments to medications used to treat diabetes that should be considered in hospitalized patients with type 2 diabetes
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: We need to understand whether any of the medications we use for type 2 diabetes therapy have any special benefits or risks that are currently not appreciated, in the context of active Coronavirus infection
Disclosures listed in article
Daniel J Drucker M.D.
“Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications,” was published online, ahead of print.
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