Higher Protein, Lower Calorie Diet Can Improve Function and Weight Loss in Older Adults

Kristen M. Beavers Assistant Professor, Department of Health and Exercise Science Department of Biostatistical Sciences Wake Forest School of Medicine Winston-Salem, NC

Dr. Beavers

MedicalResearch.com Interview with:
Kristen M. Beavers PhD, MPH, RD
Assistant Professor, Department of Health and Exercise Science
Department of Biostatistical Sciences
Wake Forest School of Medicine
Winston-Salem, NC

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Weight loss recommendation for older adults with obesity is controversial, in part because overall weight loss is accompanied by loss of muscle and bone, which may exacerbate age-related risk of disability and fracture. Identification of interventions that can preserve muscle and bone while promoting fat loss should maximize cardiometabolic benefit, while minimizing potential harm to the musculoskeletal system.

This randomized controlled trial was originally designed to test whether a higher protein, nutritionally complete meal plan could preserve lean mass and mobility in older adults undergoing a six month intentional weight loss program. Four publications have resulted from this study: * “Effect of an Energy-Restricted, Nutritionally Complete, Higher Protein Meal Plan on Body Composition and Mobility in Older Adults with Obesity,” Journals of Gerontology: Medical Sciences, published online in advance of print June 21, 2018 * “Effect of a Hypocaloric, Nutritionally Complete, Higher-Protein Meal Plan on Bone Density and Quality in Older Adults With Obesity,” American Journal of Clinical Nutrition, published online in advance of print Jan. 9, 2019 * “Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity,” Journals of Gerontology: Medical Sciences, published online in advance of print Aug. 20, 2018 * “Effects of a Hypocaloric, Nutritionally Complete, Higher Protein Meal Plan on Regional Body Fat and Cardiometabolic Biomarkers in Older Adults with Obesity,” Annals of Nutrition and Metabolism, published online in advance of print Feb. 11, 2019

Across the four publications, we found that:

* Participants lost about 18 pounds, most of it fat (87 percent), and preserved muscle mass. The control group lost about half a pound.

* Even when participants lost weight, they maintained bone mass. In fact, trabecular bone score, a measure of bone quality which predicts fracture risk, seemed to improve.

* Fat was lost in the stomach, hips, thighs and rear, which is important for preventing or controlling cardiometabolic diseases such as diabetes and stroke.

* Participants’ score on the Healthy Aging Index, which measures biomarkers that predict mortality and longevity, improved by 0.75 points.

MedicalResearch.com: What should readers take away from your report?

Response: Data from this study suggest that practitioners working with older adults with obesity can recommend a hypocaloric, nutritionally complete, higher protein meal plan and anticipate that their patients will experience significant weight loss, accompanied by a favorable shift in body composition, preservation of physical function, and improvement in several biomarkers of mortality.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: Future studies should carefully screen and recruit older adults with objectively measured functional impairment at baseline to determine if a treatment effect is enhanced in this high risk population, and examine the role of protein type and timing in intervention effectiveness. 

MedicalResearch.com: Is there anything else you would like to add?

Response: Jason Pharmaceuticals Inc., a wholly owned subsidiary of Medifast Inc., provided a grant and an in-kind donation of the products given to the research participants. Additional funding was provided by the Wake Forest Claude D. Pepper Center Older Americans Independence Center and a National Institute on Aging career development award to Beavers (K01 AG047921). 

Citation:

Ann Nutr Metab. 2019 Feb 12;74(2):149-155. doi: 10.1159/000497066. [Epub ahead of print]

Effects of a Hypocaloric, Nutritionally Complete, Higher Protein Meal Plan on Regional Body Fat and Cardiometabolic Biomarkers in Older Adults with Obesity.

Serra MC1, Beavers DP2, Henderson RM3, Kelleher JL4, Kiel JR5, Beavers KM6. 

Feb 18, 2019 @ 1:23 pm

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