Results of Molecular Testing Highly Influenced By Type of Genetic Test

MedicalResearch.com Interview with:

C. Anthony Blau, M.D. Professor of Medicine, Division of Hematology University of Washington School of Medicine Co-Director, University of Washington Institute for Stem Cell and Regenerative Medicine Director, Center for Cancer Innovation

Dr. C. Anthony Blau

C. Anthony Blau, M.D.
Professor of Medicine, Division of Hematology
University of Washington School of Medicine
Co-Director, University of Washington Institute for Stem Cell and Regenerative Medicine
Director, Center for Cancer Innovation

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Matching cancer treatment to the molecular composition of a patient’s tumor holds promise for making cancer therapies more effective, and molecular testing for cancer patients has become widespread in recent years.

Recently molecular testing of tumor samples has been complemented by blood tests that characterize tumor DNA that has been shed into the bloodstream.  Blood tests are attractive because they are much less invasive than obtaining tumor tissue via biopsies.

MedicalResearch.com: What are the main findings?

Response: In our study we compared results from commercial testing of tumor tissue (through Foundation One) and blood (from Guardant Gealth) in 9 cancer patients, and found marked discrepancies in the reported results, both with respect to the genetic changes identified, and with respect to the drugs that were recommended.

We find that the results of molecular testing are markedly influenced by the decision of which genetic test to apply.  While our findings are preliminary, further research is needed to understand and resolve these discrepancies, as these tests are used in tens of thousands of cancer patients in the US each year.

MedicalResearch.com: What should readers take away from your report?

Response: We find that the results of molecular testing are markedly influenced by the decision of which genetic test to apply.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: While our findings are preliminary, further research is needed to understand and resolve these discrepancies, as these tests are used in tens of thousands of cancer patients in the US each year.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Kuderer NM, Burton KA, Blau S, Rose AL, Parker S, Lyman GH, Blau CA. Comparison of 2 Commercially Available Next-Generation Sequencing Platforms in Oncology. JAMA Oncol. Published online December 15, 2016. doi:10.1001/jamaoncol.2016.4983

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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