17 Dec Why Doesn’t That Medicine Work For Me? Genetic Mutations Affect Drugs’ Efficacy
MedicalResearch.com Interview with:
Alexander S Hauser, PhD student
MRC Laboratory of Molecular Biology
Department of Drug Design and Pharmacology, University of Copenhagen
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The prevalence and impact of genetic variation among all human G protein coupled receptors (GPCRs) that are targeted by FDA-approved drugs remain unknown. In this study, we present a comprehensive analysis and map of the pharmacogenomics
landscape of GPCR drug targets. The key highlights are:
– GPCRs targeted by drugs show extensive genetic variation in the human population
– Variation occurs in functional sites and may result in altered drug response
– Understanding GPCR genetic variation may help reduce global healthcare expenses
MedicalResearch.com: What should clinicians and patients take away from your report?
Response: Natural genetic variation in the human genome is a cause of individual differences in responses to medications and is an underappreciated burden on public health.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Along with the study, we present an online resource of GPCR genetic variants. This online, interactive platform allows pharmacologists, molecular modelers, clinicians, and anyone interested to select and study the impact of natural variation for any drug target.
We hope that our work will inspire many scientists to characterize human variants from multiple lines of research in efforts similar to the ENCODE project.
MedicalResearch.com: Is there anything else you would like to add?
- The mutations known to date are probably only a fraction of all human genetic variants. There is still a lot to understand before we can fully embark on personalized medicine.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Alexander S. Hauser,Sreenivas Chavali, Ikuo Masuho, Leonie J. Jahn, Kirill A. Martemyanov, David E. Gloriam, M. Madan Babu
Published Online: December 14, 2017
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