Why Doesn’t That Medicine Work For Me? Genetic Mutations Affect Drugs’ Efficacy

MedicalResearch.com Interview with:

Alexander S Hauser, PhD student MRC Laboratory of Molecular Biology Cambridge UK Department of Drug Design and Pharmacology, University of Copenhagen Copenhagen, Denmark

Alexander Hauser

Alexander S Hauser, PhD student
MRC Laboratory of Molecular Biology
Cambridge UK
Department of Drug Design and Pharmacology, University of Copenhagen
Copenhagen, Denmark

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The prevalence and impact of genetic variation among all human G protein coupled receptors (GPCRs) that are targeted by FDA-approved drugs remain unknown. In this study, we present a comprehensive analysis and map of the pharmacogenomics
landscape of GPCR drug targets. The key highlights are:

– GPCRs targeted by drugs show extensive genetic variation in the human population

– Variation occurs in functional sites and may result in altered drug response

– Understanding GPCR genetic variation may help reduce global healthcare expenses

MedicalResearch.com: What should clinicians and patients take away from your report?

Response: Natural genetic variation in the human genome is a cause of individual differences in responses to medications and is an underappreciated burden on  public health.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Along with the study, we present an online resource of GPCR genetic variants. This online, interactive platform allows pharmacologists, molecular modelers, clinicians, and anyone interested to select and study the impact of natural variation for any drug target.

We hope that our work will inspire many scientists to characterize human variants from multiple lines of research in efforts similar to the ENCODE project.

MedicalResearch.com: Is there anything else you would like to add?

  • The mutations known to date are probably only a fraction of all human genetic variants. There is still a lot to understand before we can fully embark on personalized medicine.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Pharmacogenomics of GPCR Drug Targets

Alexander S. Hauser,Sreenivas Chavali, Ikuo Masuho, Leonie J. Jahn, Kirill A. Martemyanov, David E. Gloriam, M. Madan Babu
Published Online: December 14, 2017

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

 

 

 

 

 

 

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